Variation in physicochemical properties of the hypervariable region 1 during acute and chronic stages of hepatitis C virus infection

2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW) Pub Date : 2011-11-12 DOI:10.1109/BIBMW.2011.6112357

I. Astrakhantseva, David S. Campo, Aufra Araujo, C. Teo, Y. Khudyakov, S. Kamili

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引用次数: 3

Abstract

Differentiation between acute and chronic HCV infections is clinically important given that early treatment of infected patients leads to high rates of sustained virological response. Analysis of HVR1 sequences (n=2179) from samples obtained from patients with acute (n=49) and chronic (n=102) HCV infections showed that intra-host HVR1 diversity was 1.8 times higher in patients with chronic than acute infection. Analysis of molecular variance showed significant differences between sequences from acute and chronic patients. We found statistically significant differences in polarity, volume and hydrophobicity of amino acids at 10 HVR1 positions. A classification model constructed using the 10 positions in HVR1 distinguished between acute and chronic cases with accuracy of 88% in cross-validation experiments. The results indicate that progression from acute to chronic stage of HCV infection is accompanied by characteristic changes in amino acid composition of HVR1, suggesting a substantial regularity of the intra-host HVR1 evolution.

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丙型肝炎病毒感染急性和慢性阶段高变区1理化性质的变化

区分急性和慢性丙型肝炎病毒感染在临床上很重要，因为感染患者的早期治疗导致持续病毒学反应的高发率。对急性(n=49)和慢性(n=102) HCV感染患者样本的HVR1序列(n=2179)分析显示，慢性HCV感染患者的宿主内HVR1多样性是急性HCV感染患者的1.8倍。分子变异分析显示急慢性患者序列间存在显著差异。我们发现10个HVR1位点上氨基酸的极性、体积和疏水性存在统计学上的显著差异。在交叉验证实验中，利用HVR1的10个位点构建的分类模型区分急性和慢性病例，准确率为88%。结果表明，从急性到慢性HCV感染的进展伴随着HVR1氨基酸组成的特征性变化，表明宿主内HVR1的进化具有实质性的规律性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)

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