Michael P. Lisanti , Philipp E. Scherer , ZhaoLan Tang , Eric Kübler , Anthony J. Koleske , Massimo Sargiacomo
{"title":"Caveolae and human disease: functional roles in transcytosis, potocytosis, signalling and cell polarity","authors":"Michael P. Lisanti , Philipp E. Scherer , ZhaoLan Tang , Eric Kübler , Anthony J. Koleske , Massimo Sargiacomo","doi":"10.1016/S1044-5781(06)80084-8","DOIUrl":null,"url":null,"abstract":"<div><p>Caveolae are 50–100 nm invaginations that represent a sub-compartment of the plasma membrane. Recent studies have implicated these membranous structures in: (1) transcytosis of macromolecules (such as LDL and AGEs) across capillary endothelial cells; (2) potocytic uptake of small molecules via GPI-linked receptors coupled with an unknown anion transport protein; (3) certain transmembrane signalling events; and (4) polarized trafficking of GPI-linked proteins in epithelial cells. Biochemical isolation and characterization of these domains reveals the molecular components that could perform these diverse functions: scavenger receptors for oxidized LDL and AGEs, namely CD 36 and RAGE, respectively (transcytosis); plasma membrane porin (potocytosis); heterotrimeric G-proteins and Src-like kinases (signalling); and Rap GTPases (cell polarity). As such, these findings have clear implications for understanding the molecular pathogenesis of several human diseases — including atherosclerosis, diabetic vascular complications, and cancerous cell transformations.</p></div>","PeriodicalId":101155,"journal":{"name":"Seminars in Developmental Biology","volume":"6 1","pages":"Pages 47-58"},"PeriodicalIF":0.0000,"publicationDate":"1995-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1044-5781(06)80084-8","citationCount":"36","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Developmental Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1044578106800848","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 36
Abstract
Caveolae are 50–100 nm invaginations that represent a sub-compartment of the plasma membrane. Recent studies have implicated these membranous structures in: (1) transcytosis of macromolecules (such as LDL and AGEs) across capillary endothelial cells; (2) potocytic uptake of small molecules via GPI-linked receptors coupled with an unknown anion transport protein; (3) certain transmembrane signalling events; and (4) polarized trafficking of GPI-linked proteins in epithelial cells. Biochemical isolation and characterization of these domains reveals the molecular components that could perform these diverse functions: scavenger receptors for oxidized LDL and AGEs, namely CD 36 and RAGE, respectively (transcytosis); plasma membrane porin (potocytosis); heterotrimeric G-proteins and Src-like kinases (signalling); and Rap GTPases (cell polarity). As such, these findings have clear implications for understanding the molecular pathogenesis of several human diseases — including atherosclerosis, diabetic vascular complications, and cancerous cell transformations.