Pioglitazone Loaded-PLGA-PEG Nanoparticles: Drug Release and Interactions

Abstract

Extended Abstract Introduction The main obstacle to transport drugs to the brain, for neurodegenerative diseases treatment, is the blood-brain barrier (BBB), acting as an immune and metabolic barrier [1]. Pioglitazone (PGZ) is an oral anti-diabetic from thiazolidinediones, agonist of the peroxisome proliferator-activated receptors (PPARs), which could play an important role on mechanisms of neurodegenerative diseases [2, 3]. The main goal of this work was the PGZ association nanostructured systems, to nanoparticles (NPs) from poly (D,L-lactide-co-glycolide) poly(ethylene glycol) (PLGA-PEG) that are able to pass BBB.