Adiponectin, IL-6 and hsCRP: Interplay of Inflammation with Obesity and Type 2 Diabetes in Indian Population

Abstract

Purpose: To identify the association if any, of inflammatory markers (IL-6 and hsCRP) with adiponectin in obese diabetic, non-obese diabetic, obese non-diabetic and healthy (control) people in North Indian population. Materials and Methods: Total 88 volunteers were distributed in 4 groups: obese diabetic, non-obese diabetic, obese non-diabetic and healthy controls. The blood chemistry parameters were analyzed and serum adiponectin, IL-6 and hsCRP levels were measured by ELISA. Result: Significant reduction was observed in serum adiponectin levels in obese and diabetic group as compared with healthy population. Similarly, significant increase was observed in IL-6 and hs CRP levels in obese and diabetic groups compared with healthy control group. Conclusion: From our data it can be summarized that there is a significant change in both adiponectin (reduction) and IL-6 and hsCRP (increase) levels in obese diabetic, non-obese diabetic and obese non-diabetic people in Indian population. The result of our study showed that adiponectin levels are reduced in obesity and type-2 diabetes, and there is a reciprocal association of hsCRP and IL-6 in the above conditions.