Determination of Trifluoperazine hydrochloride in pharmaceutical preparations using Spectrophotometric method

Abstract

In this study a simple, sensitive and reproducible spectrophotometric method has beenused for determination of trifluoperazine hydrochloride in pure form as well as inpharmaceutical tablet preparations. This study is adopted on the oxidative coupling reactionusing 4-methoxy aniline as a new chromogenic reagent with ammonium cerium(IV) sulphatedihydrate as oxidizing agent in acidic medium to form a violet water soluble dye withabsorption at 555 nm. The molar absorptivity 17775 liter / mol .cm and the method obeyedLambert-Beer’s law in the concentration range 1.0 – 18.0 μg/ml of TFPH, the relativestandard deviation value ranges from 1.333-1.665 % depending on the concentration level ofTFPH. This study has been applied successfully to the estimation of trifluoperazinehydrochloride in two pharmaceutical preparations (Iralzin and Salabid tablets).