Role of S100β Glial Protein as a Serological Marker for Analysis of Acute Ischemic Stroke

Kiran Buddharaju, M. Javali, A. Mehta, R. Srinivasa, P. Acharya
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Abstract

Background: Stroke is a major cause of neurological disability, which can be often predicted with serological markers. Glial-derived S100β protein is a potential biomarker for cerebral ischemia and may be helpful in predicting the severity, outcome, and recovery of stroke. Aim: This study aimed to study the role of S100β glial protein as a serological marker in predicting the severity of acute ischemic stroke (AIS), outcome, and functional recovery after 1 month. Methods: A hospital-based prospective case control study included 43 consecutive patients, >18 years old, who were admitted with acute middle cerebral artery (MCA) territory infarcts within 72 h of onset of neurological deficits. Control group comprised of 43 age-matched asymptomatic volunteers. Independent t-test and chi square test were used to compare the means and evaluate the association between protein level and various parameters. P ≤ .05 was statistically significant. Results: S100β protein level in AIS patients was significantly higher compared to controls (P < .05). Elevated serum S100β protein level was found to be associated with larger infarct volumes, higher National Institute Health Stroke Scale scores, and higher modified Rankin Scale scores at admission (P < .05). Patients with higher S100β protein levels at admission had poor recovery at 1 month compared to patients having normal S100β protein levels. Conclusion: S100β protein levels at admission after an acute MCA territory infarct may be used as a reliable serological tool in predicting the severity, outcome, and functional recovery in stroke.
S100β胶质蛋白作为急性缺血性脑卒中血清学指标的作用
背景:中风是神经功能障碍的主要原因,通常可以用血清学标志物预测。神经胶质源性S100β蛋白是脑缺血的潜在生物标志物,可能有助于预测中风的严重程度、预后和恢复。目的:本研究旨在研究S100β胶质蛋白作为血清学标志物在预测急性缺血性卒中(AIS)严重程度、预后和1个月后功能恢复中的作用。方法:一项以医院为基础的前瞻性病例对照研究,纳入了43例连续患者,年龄>18岁,在神经功能障碍发病72小时内因急性大脑中动脉(MCA)区域梗死而入院。对照组由43名年龄相匹配的无症状志愿者组成。采用独立t检验和卡方检验比较均数,评价蛋白水平与各参数的相关性。P≤0.05有统计学意义。结果:AIS患者S100β蛋白水平明显高于对照组(P < 0.05)。血清S100β蛋白水平升高与入院时更大的梗死面积、更高的nih卒中量表评分和更高的修正Rankin量表评分相关(P < 0.05)。入院时S100β蛋白水平较高的患者与S100β蛋白水平正常的患者相比,1个月后恢复较差。结论:急性中动脉区域梗死入院时S100β蛋白水平可作为预测卒中严重程度、预后和功能恢复的可靠血清学工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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