Molecular Mechanisms in the Etiology of Polycystic Ovary Syndrome (PCOS): A Multifaceted Hypothesis Towards the Disease with Potential Therapeutics.

IF 1.5 4区医学 Q3 DERMATOLOGY

Melanoma Research Pub Date : 2024-01-01 Epub Date: 2023-03-18 DOI:10.1007/s12291-023-01130-7

Khair Ul Nisa, Najeebul Tarfeen, Shahnaz Ahmad Mir, Ajaz Ahmad Waza, Mir Bilal Ahmad, Bashir Ahmad Ganai

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Abstract

Among the premenopausal women, Polycystic Ovary Syndrome (PCOS) is the most prevalent endocrinopathy affecting the reproductive system and metabolic rhythms leading to disrupted menstrual cycle. Being heterogeneous in nature it is characterized by complex symptomology of oligomennorhoea, excess of androgens triggering masculine phenotypic appearance and/or multiple follicular ovaries. The etiology of this complex disorder remains somewhat doubtful and the researchers hypothesize multisystem links in the pathogenesis of this disease. In this review, we attempt to present several hypotheses that tend to contribute to the etiology of PCOS. Metabolic inflexibility, aberrant pattern of gonadotropin signaling along with the evolutionary, genetic and environmental factors have been discussed. Considered a lifelong endocrinological implication, no universal treatment is available for PCOS so far however; multiple drug therapy is often advised along with simple life style intervention is mainly advised to manage its cardinal symptoms. Here we aimed to present a summarized view of pathophysiological links of PCOS with potential therapeutic strategies.

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多囊卵巢综合征（PCOS）病因的分子机制：多囊卵巢综合征（PCOS）病因的分子机制：关于该疾病的多方面假说及潜在疗法。

在绝经前妇女中，多囊卵巢综合征（PCOS）是最常见的内分泌疾病，影响生殖系统和代谢节律，导致月经周期紊乱。该病具有异质性，其特征是症状复杂，表现为月经量少、雄激素过多引发男性化表型和/或多卵泡卵巢。这种复杂疾病的病因仍然存在疑问，研究人员假设其发病机制与多系统有关。在这篇综述中，我们试图提出几种可能导致多囊卵巢综合症病因的假说。我们讨论了代谢不灵活、促性腺激素信号传递模式异常以及进化、遗传和环境因素。多囊卵巢综合征被认为是一种终身性内分泌疾病，迄今为止还没有针对该病的通用治疗方法，但通常建议采用多种药物治疗，并主要通过简单的生活方式干预来控制其主要症状。在此，我们旨在总结多囊卵巢综合症的病理生理学联系以及潜在的治疗策略。

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来源期刊

Melanoma Research 医学-皮肤病学

CiteScore

3.40

自引率

4.50%

发文量

139

审稿时长

6-12 weeks

期刊介绍： Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.