Effect of Tarragon (Artemisia dracunculus L.) and Its Ethanolic Extracts on Chronic Liver Disease in Male Albino Rats

Abstract

Tarragon (Artemisia dracunculus L.) is a herb belonging to the Asteraceae family with a long history of protective effect and other medicinal benefits. This study aiming for studying Effect of Tarragon dried leaves and its ethanolic extracts (80%) at different concentrations on chronic liver disease. Result of chemical composition of dried tarragon leaves (protein, carbohydrates, oil, fiber and ash (23.42, 48.53, 6.99 and 7.03 g/100g, respectively) .It is rich in polyphenol, flavonoids and carotenoids contents (28.5, 15.45 and 9.98 mg/100g, respectively). Antioxidants activity in dried of tarragon leaves was high(86.43%) the major phenolic compounds were Benzoic acid, Catechein, Salycillic acid and Pyrogallol (1405.42, 8080.80, 252.71 and 213.25ppm, respectively). Also, flavonoids fractions indicated the highest content in Acacetin neo.rutinoside, Apig.6-arbinose8glactose, Apegnin, Luteolin 7-glucose and Hespirtin (907.70; 609.15; 576.54; 361.49 and 307.31 ppm, respectively). Sixty male albino rats weighted (180±20g) were fed on basal diet for two weeks before the experiment were divided to ten main groups for 60 days as follows: G1 (normal) and G2 induced CCl4, in paraffin oil (50% v/v 2ml/Kg) twice weeks for chronic damage rats of liver rats and fed on basal diet. ( G3 normal and G4 induced CCl4) fed on diet containing tarragon powder 1% ,(G5 normal, and G6 induced CCl4) fed on diet containing tarragon powder 2% ,(G7 normal and G8 induced CCl4) treated orally with(100mg/Kg wt./day) tarragon extract. (G9 normal, G10 induced CCl4) treated with 200mg/kg wt./day tarragon extract, orally . At the end of the experimental, serums were collected for determine liver and kidney functions. Results showed that decreased in AST , ALT and ALP in groups (9 and 10) which had oral tarragon extract (100 and 200mg /kg), while uric acid increased in G10 (47.67mg/dL), but was decreased creatinine in G6 (0.55mg/dL) which had taken 2% tarragon powder. Conclusively, tarragon extracts were significantly improved hepatorenal serum parameters in chronic liver disease rats groups.