Essential oil components with antidiabetic and anti-obesity properties: a review of mechanisms of action and toxicity

IF 2.2 3区农林科学 Q3 CHEMISTRY, APPLIED

Journal of Essential Oil Research Pub Date : 2023-07-04 DOI:10.1080/10412905.2023.2236625

Emmanuel U. Ejiofor, S. Oyedemi, C. Egedigwe-Ekeleme, C. Obike, Chinedu Aguwamba, P. Nweje-anyalowu, M. Ejiofor, Oluchi Okwuonu

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引用次数: 1

Abstract

ABSTRACT Diabetes and obesity are critical health concerns in the world, characterized by weak insulin secretion and activity, leading to increased blood glucose concentrations and an accumulation of excess body fat. There are conventional drugs currently used to treat these conditions, but they provide only short periods of glycemic control, are expensive, and are scarcely available in underdeveloped and developing countries. EOs are complex mixtures of aromatic and volatile compounds obtained from plants. They have numerous pharmacological and industrial applications, including anti-cancer, insecticidal, anti-microbial, anti-obesity, and antidiabetic. This review sought to investigate and organize established in vitro, in vivo, ex vivo, and in silico data, highlighting possible mechanisms of action of essential oils to treat and/or manage diabetes and obesity. The results showed that numerous essential oils from plant parts possess antidiabetic and anti-obesity properties, suggesting that essential oils can be exploited as potential antidiabetic and anti-obesity drugs.

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具有抗糖尿病和抗肥胖特性的精油成分:作用机制和毒性的综述

糖尿病和肥胖症是世界范围内严重的健康问题，其特点是胰岛素分泌和活性减弱，导致血糖浓度升高和体脂积累过多。目前有一些常规药物用于治疗这些疾病，但它们只能提供短期的血糖控制，价格昂贵，而且在不发达国家和发展中国家几乎无法获得。精油是从植物中提取的芳香族和挥发性化合物的复杂混合物。它们有许多药理和工业应用，包括抗癌、杀虫、抗微生物、抗肥胖和抗糖尿病。本综述旨在调查和整理体外、体内、离体和计算机数据，强调精油治疗和/或控制糖尿病和肥胖的可能作用机制。结果表明，许多植物部位的精油具有抗糖尿病和抗肥胖的特性，提示精油可以作为潜在的抗糖尿病和抗肥胖药物开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Essential Oil Research 工程技术-食品科技

CiteScore

6.00

自引率

3.30%

发文量

审稿时长

18-36 weeks

期刊介绍： Journal of Essential Oil Research ( JEOR) is the major forum for the publication of essential oil research and analysis. Each issue includes studies performed on the chemical composition of some of the 20,000 aromatic plants known in the plant kingdom. JEOR is devoted entirely to all phases of research from every corner of the world by the experts in their field. JEOR''s main areas of focus include: -Analytical chemistry- Biological activity- Biotechnology- Chemical composition- Chemical synthesis- Chemosystematics- Microbiological activity- Plant biochemistry/biosynthesis- Toxicology. Published six times per year, JEOR provides articles on the aromatic principles of a plant or its isolates and are directed toward furthering our readers'' knowledge of the aromatic plant and animal kingdoms.