Study on swelling behaviour of HANP/PVA composites with adding PLGA for alveolar ridge preservation

Journal of Dentomaxillofacial Science Pub Date : 2021-12-01 DOI:10.15562/jdmfs.v6i3.998

Feni Istikharoh, H. Sujuti, E. Mustamsir, Astika Swastirani

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Abstract

Objective: The aim of this study was to compare the swelling behaviour of HANP/PVA and HANP/PLGA/PVA composites. Material and Methods: This study was divided into 2 groups, HANP/ PVA and HANP/PLGA/PVA composites which prepared by freeze drying methods. HANP 20% (w/w) was combined with PLGA 20% (w/w) and dissolved in PVA solution at 50C. Swelling behaviour was obtained by measured initial weight (Wi) and the weight of composites after immersing in PBS pH 7.4; 37C for 7 days (Ws). Statistical analysis based on Independent T-test (p<0.05). Results: The initial weight (Wi) of HANP/PVA and HANP/PLGA/PVA composites are 467±4.73 and 292±9.52. The swollen weight (Ws) of HANP/PVA and HANP/PLGA/PVA composites are 897±26.61 and 860±32.36. Furthermore, the water retention of HANP/PVA composite is 92.07% (p<0.05) and HANP/PLGA/PVA composite is 194.52% (p<0.05). Conclusion: The addition of PLGA enhance swelling behaviour of HANP/PVA composites. The strong interaction between HANP and PVA decrease the swelling re. HANP is inert in nature, but the combination of HANP/PLGA/PVA can be a good substitute for alveolar preservation.

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添加PLGA用于牙槽嵴保存的HANP/PVA复合材料膨胀行为研究

目的:比较HANP/PVA和HANP/PLGA/PVA复合材料的膨胀行为。材料与方法:本研究分为两组，分别是冷冻干燥法制备的HANP/ PVA和HANP/PLGA/PVA复合材料。HANP 20% (w/w)与PLGA 20% (w/w)混合，在50C的PVA溶液中溶解。在pH为7.4的PBS中浸泡后，通过测量初始重量(Wi)和复合材料的重量来获得膨胀行为;37℃，7天(Ws)。采用独立t检验进行统计学分析(p<0.05)。结果:HANP/PVA复合材料和HANP/PLGA/PVA复合材料的初始质量(Wi)分别为467±4.73和292±9.52。HANP/PVA和HANP/PLGA/PVA复合材料的膨胀质量(Ws)分别为897±26.61和860±32.36。HANP/PVA复合材料保水率为92.07% (p<0.05)， HANP/PLGA/PVA复合材料保水率为194.52% (p<0.05)。结论:PLGA的加入增强了HANP/PVA复合材料的膨胀性能。HANP与PVA之间的强相互作用减少了肺泡的肿胀，HANP本身是惰性的，但HANP/PLGA/PVA的组合可以很好地替代肺泡的保存。

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