Effect of Varenicline on Detrusor Overactivity in Rat Model of Parkinson’s Disease Induced by Intranigral 6-Hydroxydopamine

Advances in Parkinson's Disease Pub Date : 2022-01-01 DOI:10.4236/apd.2022.111001

Z. Altunay, Fatma Rüyal Tan, Nermin Bölükbaşı, F. B. Hatip, I. hatip-Al-Khatib

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引用次数: 1

Abstract

Background: Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Bladder dysfunction is the common non-motor symptom of PD, most often presenting with detrusor overactivity (DO). Treatment of DO is currently limited, poorly tolerated and sometimes ineffective. Bladder responses are not only mediated by muscarinic cholinergic receptors (mAChR) but also by nicotinic cholinergic receptors (nAChR). However, nicotinic receptor subtypes and functions in the bladder are not clearly identified. Purpose: This study aimed at investigating the effect of varenicline, an alpha7 full agonist and alpha4beta2/alpha3 partial agonist, on detrusor strips in rat PD model induced by substantia nigra injection of 6-hydroxydopamine. Method: The detrusor activity was studied in an isolated organ bath system. Results: In PD group, the detrusor activity was increased, whereas varenicline decreased the DO. Conclusion: Alpha7 nAChR agonists may have therapeutic potential in treatment of bladder overactivity

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伐尼克兰对6-羟多巴胺诱导的帕金森病大鼠逼尿肌过度活动的影响

背景:帕金森病(PD)是一种以运动和非运动症状为特征的进行性神经退行性疾病。膀胱功能障碍是PD常见的非运动症状，最常表现为逼尿肌过度活动(DO)。目前对DO的治疗是有限的，耐受性差，有时无效。膀胱反应不仅由毒蕈碱胆碱能受体(mAChR)介导，也由烟碱胆碱能受体(nAChR)介导。然而，烟碱受体在膀胱中的亚型和功能尚不清楚。目的:观察α 7完全激动剂和α 4 β 2/ α 3部分激动剂伐尼克兰对黑质注射6-羟多巴胺致大鼠PD模型逼尿肌条的影响。方法:在离体器官浴系统中研究逼尿肌的活性。结果:PD组逼尿肌活性升高，伐尼克兰使DO降低。结论:Alpha7 nAChR激动剂对膀胱过度活动具有治疗潜力

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Advances in Parkinson's Disease

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