{"title":"The genetic characteristics of the osteoporosis phenotype","authors":"A. J. MacGregor","doi":"10.1046/j.1466-9218.2000.00016.x","DOIUrl":null,"url":null,"abstract":"<p>Osteoporosis fits well into the category of complex disease with multiple genes and environmental factors likely to be involved in its development. The osteoporosis phenotype itself comprises a number of component parts, aspects of which are captured differently by a range of different clinical and laboratory measurements. This review discusses the nature of the genetic factors that underlie this complex phenotype and considers approaches that take into account this complexity in modelling the effects of specific genes.</p>","PeriodicalId":100575,"journal":{"name":"GeneScreen","volume":"1 2","pages":"73-76"},"PeriodicalIF":0.0000,"publicationDate":"2008-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1466-9218.2000.00016.x","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"GeneScreen","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1046/j.1466-9218.2000.00016.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Osteoporosis fits well into the category of complex disease with multiple genes and environmental factors likely to be involved in its development. The osteoporosis phenotype itself comprises a number of component parts, aspects of which are captured differently by a range of different clinical and laboratory measurements. This review discusses the nature of the genetic factors that underlie this complex phenotype and considers approaches that take into account this complexity in modelling the effects of specific genes.
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