Detection of Hepatitis viruses (HBV, HAV, HCV) in serum using MEMS based Bio-Sensor

Abstract

A biosensor is a device that converts naturally occurring activity into measurable signal. Biosensors stands up for its special features such as miniaturization, easily usable, one-step reagent less analysis etc. that pave a separate way when compared to conventional biological sensing techniques. Most conventional MEMS and NEMS are designed for detecting and sensing. The working principle varies as per application, the nature of the analyte molecules, and the accuracy required. Sensing methods vary according to device such as piezo-resistance, capacitance, resonance etc. In this paper, we implement the structures using comsol software. This biosensor can detect Hepatitis viruses (HBV, HAV, HCV) by immobilizing specific antibodies on the sensing element of the sensor when the patient sample containing hepatitis viruses surface antibody (anti-HbsAg)is placed on the sensing part, Biochemical interactions take place between Hepatitis viruses antigens and the antibodies fixed on the surface of the sensing element. Due to this, beam structure changes so that disease can be detected.