{"title":"An Orientation to Implementation Science in Cancer","authors":"David A. Chambers, W. Norton, Cynthia A. Vinson","doi":"10.1093/med/9780190647421.003.0001","DOIUrl":null,"url":null,"abstract":"THE ROOTS of implementation science (IS) in cancer in some sense date back to the earliest days of uncovering cancer’s etiology, diagnosis, prevention, and treatment, although it was not called that. Indeed, unlocking the mysteries of cancer and determining effective ways to intervene began not in the lab but, rather, the clinic. As Mukherjee recounted in the seminal work, The Emperor of All Maladies, 1 cancer had been the subject of clinical examination for centuries, and the drive to optimize care began in those early days. As opposed to the largely separate worlds of research discovery and care delivery that exist today, scientific research and cancer treatment coexisted. In addition, epidemiologic observations of risk factors affecting oncogenesis developed targets for what types of prevention programs needed to be implemented. Naturally, the challenges of what exactly to implement and how best to implement have been with us throughout time.","PeriodicalId":19711,"journal":{"name":"Oxford Medicine Online","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oxford Medicine Online","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/med/9780190647421.003.0001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
THE ROOTS of implementation science (IS) in cancer in some sense date back to the earliest days of uncovering cancer’s etiology, diagnosis, prevention, and treatment, although it was not called that. Indeed, unlocking the mysteries of cancer and determining effective ways to intervene began not in the lab but, rather, the clinic. As Mukherjee recounted in the seminal work, The Emperor of All Maladies, 1 cancer had been the subject of clinical examination for centuries, and the drive to optimize care began in those early days. As opposed to the largely separate worlds of research discovery and care delivery that exist today, scientific research and cancer treatment coexisted. In addition, epidemiologic observations of risk factors affecting oncogenesis developed targets for what types of prevention programs needed to be implemented. Naturally, the challenges of what exactly to implement and how best to implement have been with us throughout time.
从某种意义上说,实施科学(IS)在癌症领域的根源可以追溯到发现癌症病因、诊断、预防和治疗的早期,尽管它不被称为实施科学。事实上,揭开癌症的奥秘并确定有效的干预方法并非始于实验室,而是始于临床。正如慕克吉在其开创性著作《万病之王》(the Emperor of All diseases)中所述,几个世纪以来,癌症一直是临床检查的主题,而优化治疗的动力从早期就开始了。与目前存在的研究发现和护理服务的两个截然不同的世界不同,科学研究和癌症治疗是共存的。此外,对影响肿瘤发生的危险因素的流行病学观察为需要实施的预防方案制定了目标。当然,我们一直都面临着具体实施什么以及如何最好地实施的挑战。