Novel Perylene-Based Antimicrobial PDI Chromophores

Cansu Yilmaz, P. Güner, T. Askun, Funda Yükrük
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引用次数: 0

Abstract

The main goal of the study was to monitor the Antimicrobial activity of two novel perylene diimides which were synthesized and characterized. Antimicrobial activity was investigated against Four Mycobacterium tuberculosis strains (MT) (Mt-H37Rv, Mt-H37Ra and two clinical isolates) and two Staphylococcus aureus strains [Methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus (SA)]. Minimum inhibitory concentrations (MICs) and minimum bactericidal activity (MBCs) were determined. Both compounds exhibited bactericidal effects and MICs were found to be changing in the range of 48-96 µg/mL for four MT-strains. Compounds were also effective on Staphylococcus strains at MIC = 96 µg/mL.
新型苝抗菌PDI发色团
本研究的主要目的是对合成并表征的两种新型苝二亚胺的抗菌活性进行监测。研究了4株结核分枝杆菌(MT - h37rv、MT - h37ra和2株临床分离株)和2株金黄色葡萄球菌(耐甲氧西林金黄色葡萄球菌(MRSA)和金黄色葡萄球菌(SA))的抗菌活性。测定了最低抑菌浓度(mic)和最低杀菌活性(MBCs)。两种化合物均表现出杀菌作用,4株mt菌株的mic在48 ~ 96µg/mL范围内变化。当MIC = 96µg/mL时,化合物对葡萄球菌菌株也有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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