The Clinicopathological and Genetic Characteristics of High-grade Gliomas with Histone H3.3 G34 Mutation in Teenagers and Young adults

Abstract

33 Chromatin is composed of nucleosomes, with each nucleosome consisting of an octamer of two copies each of histones H3, H4, H2A, and H2B. Chromatin is critical for the control of transcription, replication, DNA repair and other aspects of genomic stability. In humans, there are different histone H3 variants. H3.3 proteins are expressed thoughout the cell cycle as well as in quiescent cells [1], while H3.1 and H3.2 are expressed only during the S-phase [2].