STUDY OF ASPIRIN EFFECT ON STABILITY OF MEMBRANES OF RAT BLOOD ERYTHROCYTES BY ACIDIC HEMOLYSIS METHOD

M. Mikaelyan, M. Shahinyan, G. Poghosyan, Evelina G. Sargsyan, Anahit V. Nerkararyan
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引用次数: 1

Abstract

In this work the effect of aspirin on stability of rat blood erythrocyte membranes was studied, using acidic hemolysis method. Hemolysis rate of erythrocytes was shown to depend on preservation time of rat erythrocyte suspension. With increasing of preservation time the original value of optic density of rat erythrocyte suspension decreases and hemolysis time reduces. It was also shown that in the presence of aspirin the membrane stability of low-stable erythrocytes increases, moreover, hemolysis duration enhances, while aspirin leads to decreasing of membrane stability of both high-stable and enhanced-stable erythrocytes of rats.
酸性溶血法研究阿司匹林对大鼠红细胞膜稳定性的影响
本文采用酸性溶血法研究阿司匹林对大鼠红细胞膜稳定性的影响。红细胞溶血率与红细胞悬液保存时间有关。随着保存时间的延长,大鼠红细胞悬液光密度原始值降低,溶血时间缩短。结果表明,阿司匹林可提高大鼠低稳定型红细胞的膜稳定性,延长溶血时间,而阿司匹林可降低大鼠高稳定型和增强稳定型红细胞的膜稳定性。
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