The Foundation of Toxicology’s Dose x Time = Constant Paradigm in Physics

Abstract

The relationship dose x time = constant (mg · hr) has been reported in many toxicological experiments during the past 100 years. It was handled as a curiosity until Rozman and Doull pointed out that it can be found in every experi- ment that is conducted under equilibrium conditions which is called steady state in pharmacology and toxicology. This manuscript suggests that this relationship is consistent with the most basic laws of physics.