Prevalence and Maternal Effects of Hypothyroidism in Pregnancy

Chattagram Maa-O-Shishu Hospital Medical College Journal Pub Date : 2021-11-11 DOI:10.3329/cmoshmcj.v20i2.56467

M. Ferdousi, A. Baki

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Abstract

Background: Thyroid disorders are among the common endocrine problems in pregnant women. It is now well established that not only overt but subclinical thyroid dysfunction also has adverse effects on maternal and fetal outcome. There are few data from Bangladesh about the prevalence of thyroid dysfunction in pregnancy. With this background, this study aims to find prevalence of thyroid dysfunction in pregnancy and its impact on obstetrical outcome. Materials and methods: It is an observational study done in a Combined Military Hospital (CMH) Chattogram during the period from February to December 2020 on 130 hypothyroid mothers to observe maternal effects of hypothyroidism. Patients were collected as per inclusion and exclusion criteria after informed written consent. Data was compiled and analyzed and presented. Results: Among 1148 total patients,1018(89%) were normal and 130(11%) were diagnosed as hypothyroid.Among all the patients, 35% patientsare from inside the Chattogram and 65% are from outside. Among 130 hypothyroid cases age range revealed 20-45 years and 20 -30 years age group were 82(63.07%), 30-40 years age group was 40(30.76%) and >40 years age group were 8(6.15%). Primigravida was 48(36.92%) cases and multigravida was 82(63.08%) cases, anemia was present in 40(30.76%) cases, 10(7.69%) patients had hypertension, GDM and DM was found in 20(15.38%)and 3(2.30%) cases respectively, preconception hypothyroidism was found in 10(7.69%) and on Levothyroxine during ANC was 120(92.30%).Among all, 63(48.46%) cases were underwent vaginal delivery and 67(51.53%) cases underwent cesarean section. Untreated and irregular treatment in hypothyroidism are associated with pregnancy complications like spontaneous miscarriage 40(30.76%), maternal anaemia 55(42.30%), pre-eclampsia 4(3.07%), pre term birth 16(12.30%), postpartum haemorrhage 3(2.30%). Conclusion: Hypothyroidism is a common clinical condition during pregnancy and it causes variable pregnancy outcome Chatt Maa Shi Hosp Med Coll J; Vol.20 (2); July 2021; Page 18-21

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妊娠期甲状腺功能减退症的患病率及其对母体的影响

背景:甲状腺疾病是孕妇常见的内分泌问题之一。现在已经确定，不仅是显性的，而且是亚临床的甲状腺功能障碍也对母体和胎儿的结局有不良影响。孟加拉国关于妊娠期甲状腺功能障碍患病率的数据很少。在此背景下，本研究旨在发现妊娠期甲状腺功能障碍的患病率及其对产科结局的影响。材料与方法:于2020年2月至12月在某军区联合医院(CMH)进行130例甲状腺功能减退产妇的观察性研究，观察甲状腺功能减退对产妇的影响。经知情书面同意后，按照纳入和排除标准收集患者。对数据进行了汇编、分析和展示。结果:1148例患者中，正常1018例(89%)，甲状腺功能减退130例(11%)。在所有患者中，35%的患者来自Chattogram内，65%的患者来自Chattogram外。130例甲状腺功能减退患者中，20 ~ 45岁和20 ~ 30岁年龄组82例(63.07%)，30 ~ 40岁年龄组40例(30.76%)，40岁以上年龄组8例(6.15%)。初孕48例(36.92%)，多孕82例(63.08%)，贫血40例(30.76%)，高血压10例(7.69%)，GDM和DM分别20例(15.38%)和3例(2.30%)，孕前甲状腺功能减退10例(7.69%)，产前使用左甲状腺素120例(92.30%)。其中阴道分娩63例(48.46%)，剖宫产67例(51.53%)。甲状腺功能减退症患者未经治疗和治疗不规范与自然流产40(30.76%)、母体贫血55(42.30%)、子痫前期4(3.07%)、早产16(12.30%)、产后出血3(2.30%)等妊娠并发症相关。结论:甲状腺功能减退是妊娠期常见的临床疾病，并可导致妊娠结局的变化。期(2);2021年7月;第18 - 21页

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Chattagram Maa-O-Shishu Hospital Medical College Journal

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