The Value of Intravoxel Incoherent Motion (IVIM) Magnetic Resonance Imaging in the Evaluation of the Osteosarcoma Response to Preoperative Neoadjuvant Chemotherapy in Teens

IF 0.4 4区化学 Q4 CHEMISTRY, PHYSICAL

Concepts in Magnetic Resonance Part A Pub Date : 2019-05-09 DOI:10.1155/2019/2918763

Hou-dong Zuo

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引用次数: 2

Abstract

Purpose. To investigate the value of intravoxel incoherent motion (IVIM) magnetic resonance imaging in the evaluation of the osteosarcoma (OS) response to preoperative neoadjuvant chemotherapy (NAC) in teens. Methods. Eighteen consecutive osteosarcoma patients (12 males and 6 females) diagnosed by histopathology were enrolled. All enrolled patients received NAC and underwent MRI examinations before and after 2 cycles of NAC. The volume (V), apparent diffusion coefficient (ADC), (slow) diffusion coefficient (D), pseudo-perfusion (fast) diffusion coefficient (D⁎or D star), and perfusion fractions (f) of the OS before and after NAC were measured and analysed. The sensitivity and the specificity of the ADC, D, D⁎ and f values and the correlation between changes in volume (ΔV) and the IVIM-derived parameters (ΔADC, ΔD, ΔD⁎ and Δf) were also calculated and analysed. Paired Student’s t-tests, receiver operating characteristic (ROC) curves, and Spearman correlation analyses were used. Results. The mean volume of the OS after NAC decreased significantly (61.55±9.3 cm3 vs 40.26±4.1 cm3) (P<0.05). After NAC, the ADC (1.21±0.09 × 10-3 mm2/s vs 1.73±0.11 × 10-3 mm2/s) and D (1.14±0.09 × 10-3 mm2/s vs 1.63±0.1 × 10-3 mm2/s) values increased and f (28.58±1.37% vs 20.93±1.16%) values decreased significantly (P<0.05), while D⁎ (9.17±0.98 × 10-3 mm2/s vs 8.94±0.13 × 10-3 mm2/s) values changed slightly (P>0.05). The AUC values of ADC (0.938) and D (0.943) were higher than those of D⁎ (0.574) and f (0.765). The sensitivity and specificity of ADC (0.778, 1) and D (0.944, 0.833) values were superior to those of D⁎ (0.278, 0.722) and f (0.5, 0.944) values. No significant correlations were found between the ΔV and ΔADC, ΔD, ΔD⁎ and Δf values (P>0.05). Conclusion. IVIM-derived parameters ADC and D have the potential to be imaging biomarkers for evaluation of the therapeutic response to NAC in OS patients.

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体素内非相干运动(IVIM)磁共振成像在评估青少年骨肉瘤术前新辅助化疗反应中的价值

目的。探讨体素内非相干运动(IVIM)磁共振成像在评估青少年骨肉瘤(OS)术前新辅助化疗(NAC)反应中的价值。方法。本研究纳入18例经组织病理学诊断的连续骨肉瘤患者(男12例，女6例)。所有入组患者均接受NAC治疗，并在NAC治疗前后分别进行MRI检查。测定并分析NAC前后OS的体积(V)、表观扩散系数(ADC)、(慢)扩散系数(D)、伪灌注(快)扩散系数(D或D *)、灌注分数(f)。计算并分析ADC、D、D、f值的敏感性和特异性，以及体积变化(ΔV)与ivim衍生参数(ΔADC、ΔD、ΔD 和Δf)之间的相关性。采用配对学生t检验、受试者工作特征(ROC)曲线和Spearman相关分析。结果。NAC后OS平均体积明显减小(61.55±9.3 cm3 vs 40.26±4.1 cm3) (P0.05)。ADC(0.938)和D(0.943)的AUC值高于D(0.574)和f(0.765)。ADC(0.778, 1)和D(0.944, 0.833)值的敏感性和特异性均优于D(0.278, 0.722)和f(0.5, 0.944)值。ΔV与ΔADC、ΔD、ΔD、Δf值无显著相关(P < 0.05)。结论。ivim衍生的参数ADC和D有潜力成为评估OS患者对NAC治疗反应的成像生物标志物。

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来源期刊

Concepts in Magnetic Resonance Part A 物理-光谱学

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Concepts in Magnetic Resonance Part A brings together clinicians, chemists, and physicists involved in the application of magnetic resonance techniques. The journal welcomes contributions predominantly from the fields of magnetic resonance imaging (MRI), nuclear magnetic resonance (NMR), and electron paramagnetic resonance (EPR), but also encourages submissions relating to less common magnetic resonance imaging and analytical methods. Contributors come from academic, governmental, and clinical communities, to disseminate the latest important experimental results from medical, non-medical, and analytical magnetic resonance methods, as well as related computational and theoretical advances. Subject areas include (but are by no means limited to): -Fundamental advances in the understanding of magnetic resonance -Experimental results from magnetic resonance imaging (including MRI and its specialized applications) -Experimental results from magnetic resonance spectroscopy (including NMR, EPR, and their specialized applications) -Computational and theoretical support and prediction for experimental results -Focused reviews providing commentary and discussion on recent results and developments in topical areas of investigation -Reviews of magnetic resonance approaches with a tutorial or educational approach