Structural proteins of SARS-CoV-2

Abstract

The review presents the basic information available in the literature on the structural proteins of SARS-CoV-2 (S;N;E;M). Issues affecting the importance of these proteins in the pathogenesis, adaptation and life cycle of the virus are discussed. Structural multifunctional proteins are biomarkers of increased contagiousness and pathogenicity of SARS-CoV-2, forming its pathogenetic and adaptive potential. The multifunctionality of the structural proteins of the new coronavirus allows it to respond quickly to fluctuations in the conditions of existence through the use of alternative approaches to implement the mechanisms underlying its pathogenetic potential. Currently, the structure, properties, functions and role of structural proteins of SARS-CoV-2 are being actively studied, which is an actual vector of research that allows us to decipher the mechanisms underlying its high contagiousness, pathogenicity, adaptation, and in the future to evaluate possible ways of forming its new variants and develop a strategy and tactics of emergency response when it appears new strains.The prospects of further study of the structure and properties of structural proteins for solving the priority tasks of the present time on the creation of modern domestic vaccines and effective methods of diagnosis, treatment and prevention of a new coronavirus are noted.The authors analyzed scientific publications from various databases of electronic libraries, such as PubMed, e-library, CyberLeninka, etc.