All Hazards Receipt Facility (AHRF) Testing Algorithm Modifications for Enhanced Screening and Safety

Michael J. Perry, Alan J Antenucci, Cass, ra D Kelly-Cirino, M. Heyl, K. Aldous, C. Egan
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Abstract

After the terrorist events of 2001, it became rapidly apparent that a comprehensive laboratory detection and response capacity was urgently needed. In the past decade significant work has been done at the local, state and federal level to increase our nation’s emergency response framework. An integral part of this system was the development and construction of the All Hazards Receipt Facility by the Department of Homeland Security. The AHRF is a mobile, selfcontained laboratory designed to screen uncharacterized suspicious substances for chemical, radiological, nuclear, and explosive threats prior to acceptance at a Laboratory Response Network facility, or other testing laboratory. The Wadsworth Centre, New York State Department of Health was one of two sites selected to evaluate the prototype AHRF unit and exercise the testing algorithms for rule out of acute hazards. The original testing algorithm, developed by the Department of Homeland Security and Environmental Protection Agency, has been revised and updated by the Wadsworth Centre’s Biodefense Laboratory. The improved screening protocol enhances the safety of laboratory staff, mitigates hazards that could cause serious damage to the facility and increases public safety. In addition, the modified testing algorithm was developed to streamline sample testing. The changes have significantly decreased result turnaround- times, allow for increased sample throughput thus enhancing workflow. The All Hazards approach to sample analysis requires comprehensive testing of multiple threats with minimal sample destruction to ensure sufficient sample remains for both evidentiary and confirmatory testing. Our screening protocol combines non-destructive handheld detectors and limited sample volume colorimetric test kits to achieve this goal.
所有危险接收设施(AHRF)测试算法修改,以增强筛选和安全性
2001年恐怖事件发生后,人们迅速意识到,迫切需要一个全面的实验室检测和反应能力。在过去的十年里,地方、州和联邦各级都做了大量的工作来加强我们国家的应急响应框架。该系统的一个组成部分是由国土安全部开发和建设的“所有危险接收设施”。AHRF是一个移动的、独立的实验室,用于在实验室响应网络设施或其他测试实验室接受之前筛选未表征的可疑物质,以检测化学、放射性、核和爆炸威胁。纽约州卫生部Wadsworth中心是选定的两个地点之一,用于评估AHRF原型装置并执行排除急性危害的测试算法。最初的测试算法是由国土安全部和环境保护局开发的,已经由沃兹沃思中心的生物防御实验室进行了修订和更新。改进后的筛选方案提高了实验室工作人员的安全,减轻了可能对设施造成严重损害的危险,并提高了公共安全。此外,开发了改进的测试算法,简化了样本测试。这些变化大大减少了结果周转时间,允许增加样品吞吐量,从而增强了工作流程。样品分析的全危害方法要求以最小的样品破坏对多种威胁进行全面测试,以确保有足够的样品用于证据和确认性测试。我们的筛选方案结合了非破坏性手持探测器和有限样品体积比色测试试剂盒来实现这一目标。
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