High-throughput structural genomics and proteomics: where are we now?

Jeff Yon, Harren Jhoti
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引用次数: 5

Abstract

Since its initiation 3–4 years ago, the emerging field of structural genomics has faced many technical obstacles on the path to high-throughput protein structure determination. Although attrition in the gene-to-structure process remains high, much has been achieved and the first genome-scale studies are appearing in the literature. In terms of drug discovery, high-throughput structure determination is leading to increases in productivity, and to new approaches to hit identification.

高通量结构基因组学和蛋白质组学:我们现在在哪里?
自3-4年前开始,结构基因组学这一新兴领域在高通量蛋白质结构测定的道路上面临着许多技术障碍。虽然在基因到结构的过程中损耗仍然很高,但已经取得了很大的成就,并且首次基因组规模的研究正在文献中出现。在药物发现方面,高通量结构测定正在导致生产力的提高,并为命中识别提供新的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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