CHAPTER 11. Noncovalent Interactions in the Nitroaldol (Henry) Reaction

S. Hazra, A. Pombeiro
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引用次数: 2

Abstract

The Henry (nitroaldol) reaction provides a useful method for C–C bond formation between a nitroalkane and an aldehyde or a ketone to form a β-nitro alcohol. Noncovalent interactions can play important roles in this reaction, namely by orienting the reactant molecules, lowering the reaction barriers or even building suitable supramolecular catalysts. This chapter considers the influence of noncovalent interactions (mainly H-bonding) in the Henry reaction (excluding the aza-Henry reaction) and the product selectivity including diastereoselectivity (anti or syn) and enantioselectivity.
第十一章。硝基醛(Henry)反应中的非共价相互作用
亨利(硝基醛)反应为硝基烷烃与醛或酮之间形成C-C键生成β-硝基醇提供了一种有用的方法。非共价相互作用可以在该反应中发挥重要作用,即定向反应物分子,降低反应势垒甚至构建合适的超分子催化剂。本章考虑了Henry反应(不包括aza-Henry反应)中非共价相互作用(主要是氢键)的影响以及产物的选择性,包括非对映选择性(反或顺)和对映选择性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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