Effect of satiety on TSH and free thyroxin levels in healthy individuals and patients with subclinical and overt hypothyroidism

Clinical and experimental thyroidology Pub Date : 2021-06-15 DOI:10.14341/KET12691

M. G. Kilinçarslan, C. Çelik, E. Şahi̇n

{"title":"Effect of satiety on TSH and free thyroxin levels in healthy individuals and patients with subclinical and overt hypothyroidism","authors":"M. G. Kilinçarslan, C. Çelik, E. Şahi̇n","doi":"10.14341/KET12691","DOIUrl":null,"url":null,"abstract":"Background: Thyroid stimulating hormone (TSH) and thyroxine levels may change according to fasting — satiety status. AIM: The aim of this study was to determine the effect of satiety on TSH and free thyroxine levels.Methods: This study was conducted in a tertiary hospital. According to previous TSH and thyroxine levels, groups of 30, 30 and 60 participants were designated as subclinical hypothyroidism, hypothyroidism, and control groups respectively. To obtain TSH and thyroxine results first phlebotomy was performed at 8 am while participants were in fasting state. Then participants were allowed to have non-standardized breakfast. Second phlebotomy was performed at 10 am while participants were in non-fasting state. Paired t-test and ANOVA were used to analyze the data.Results: The fasting TSH levels of the participants (2.57 ± 1.84 mlU/L) were significantly higher than the satiety TSH levels (2.04 ± 1.48 mlU/L) (t = 8.566, p < 0.001, d = 0.80). The fasting free thyroxine values (1.31 ± 0.38 mg/dl) of the participants were significantly lower than the satiety free thyroxine values (1.39 ± 0.35 mg/dl) (t = -1.988, p = 0.049, d = 0.20).Conclusion: Knowing how TSH and free thyroxine tests are affected by satiety has the power to affect treatment of many patients. Our study has shown that both TSH and free thyroxine levels changed significantly according to satiety status.","PeriodicalId":10284,"journal":{"name":"Clinical and experimental thyroidology","volume":"55 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and experimental thyroidology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14341/KET12691","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Thyroid stimulating hormone (TSH) and thyroxine levels may change according to fasting — satiety status. AIM: The aim of this study was to determine the effect of satiety on TSH and free thyroxine levels.Methods: This study was conducted in a tertiary hospital. According to previous TSH and thyroxine levels, groups of 30, 30 and 60 participants were designated as subclinical hypothyroidism, hypothyroidism, and control groups respectively. To obtain TSH and thyroxine results first phlebotomy was performed at 8 am while participants were in fasting state. Then participants were allowed to have non-standardized breakfast. Second phlebotomy was performed at 10 am while participants were in non-fasting state. Paired t-test and ANOVA were used to analyze the data.Results: The fasting TSH levels of the participants (2.57 ± 1.84 mlU/L) were significantly higher than the satiety TSH levels (2.04 ± 1.48 mlU/L) (t = 8.566, p < 0.001, d = 0.80). The fasting free thyroxine values (1.31 ± 0.38 mg/dl) of the participants were significantly lower than the satiety free thyroxine values (1.39 ± 0.35 mg/dl) (t = -1.988, p = 0.049, d = 0.20).Conclusion: Knowing how TSH and free thyroxine tests are affected by satiety has the power to affect treatment of many patients. Our study has shown that both TSH and free thyroxine levels changed significantly according to satiety status.

查看原文本刊更多论文

饱腹感对健康个体及亚临床和显性甲状腺功能减退患者TSH和游离甲状腺素水平的影响

背景:促甲状腺激素(TSH)和甲状腺素水平可根据空腹饱腹状态发生变化。目的:本研究的目的是确定饱腹感对TSH和游离甲状腺素水平的影响。方法:本研究在某三级医院进行。根据受试者之前的TSH和甲状腺素水平，将30人、30人和60人分别分为亚临床甲状腺功能减退组、甲状腺功能减退组和对照组。为了获得TSH和甲状腺素的结果，首先在参与者空腹状态下于上午8点进行静脉切开术。然后参与者被允许吃非标准化的早餐。第二次放血于上午10点进行，受试者处于非禁食状态。采用配对t检验和方差分析对数据进行分析。结果:受试者空腹TSH水平(2.57±1.84 mlU/L)显著高于饱腹期TSH水平(2.04±1.48 mlU/L) (t = 8.566, p < 0.001, d = 0.80)。空腹游离甲状腺素值(1.31±0.38 mg/dl)显著低于饱腹期游离甲状腺素值(1.39±0.35 mg/dl) (t = -1.988, p = 0.049, d = 0.20)。结论:了解TSH和游离甲状腺素测试如何受饱腹感的影响，对许多患者的治疗有很大的影响。我们的研究表明，TSH和游离甲状腺素水平根据饱腹状态发生显著变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical and experimental thyroidology

自引率

0.00%

发文量