Review of Molecular Approaches in Leishmaniasis Vaccines: Implications and Restrictions

Ail Fattahi Bafghi, E. Rezaee, S. Ahmadi, Mostafa Gholamrezaei, Nima Firouzeh
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Abstract

: Leishmaniasis, a cosmopolitan parasitic infection, is a sandfly-borne parasitic disease caused by different species of Leishmania. Many attempts have been made to discover effective and safe vaccines against leishmaniasis, but most of them are not accompanied by promising results. During the last decade, the characterization of new antigens for potential vaccine candidates based on classical and molecular protocols has been a hot research topic in immunological science. The present review focuses on the development and the status of various vaccines and potential vaccine candidates against leishmaniasis. Here, molecular approaches to leishmaniasis vaccine development are described. Also, implications and restrictions are discussed.
利什曼病疫苗分子方法综述:意义和限制
:利什曼病是一种世界性寄生虫感染,是由不同种类的利什曼原虫引起的一种由白蛉传播的寄生虫病。为发现有效和安全的利什曼病疫苗已进行了许多尝试,但其中大多数都没有带来令人鼓舞的结果。在过去的十年中,基于经典和分子协议的潜在候选疫苗新抗原的表征一直是免疫学科学的一个热门研究课题。目前的审查重点是发展和现状的各种疫苗和潜在的候选疫苗对抗利什曼病。本文描述了利什曼病疫苗开发的分子方法。此外,还讨论了影响和限制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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