Review papers Role of topical combination drug containing clindamycin and benzoyl peroxide 279 in the treatment of common acne

M. Pastuszka, A. Kaszuba
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Abstract

Common acne is a very frequent disorder of sebaceous glands which affects mainly young people. In the majority of patients (85%) acne is mild to moderate, and amenable to topical therapy. According to the European Evidencebased (S3) Guidelines for the Treatment of Acne, therapy of comedonal acne should begin with topical retinoids (preferably adapalene), while mild to moderate cases of papulopustular acne should be initially treated with com bination drugs (clindamycin + benzoyl peroxide or adapalene + benzoyl peroxide). It needs to be stressed that all of the above-mentioned combination drugs demonstrate similar efficacy in terms of reducing the number of skin lesions, both inflammatory and non-inflammatory. The onset of therapeutic effect, however, has been shown to be significantly more rapid with the clindamycin + benzoyl peroxide combination. Moreover, the combination is much better tolerated by patients than adapalene + benzoyl peroxide, and has a greater safety profile, as demonstrated in a clinical trial involving a total of 382 patients suffering from common acne. The present article discusses the prop erties of individual components of the combination drugs listed above, and compares both combinations in terms of their therapeutic efficacy, tolerability and safety.
外用克林霉素与过氧化苯甲酰279联合用药在治疗常见痤疮中的作用
普通痤疮是一种非常常见的皮脂腺疾病,主要影响年轻人。大多数患者(85%)的痤疮是轻度到中度的,可以局部治疗。根据欧洲基于证据(S3)的痤疮治疗指南,粉刺的治疗应该从局部类维生素a(最好是阿达帕林)开始,而轻度至中度丘疹性痤疮的治疗应该最初使用联合药物(克里霉素+过氧化苯甲酰或阿达帕林+过氧化苯甲酰)。需要强调的是,上述所有联合用药在减少皮肤病变数量方面,无论是炎症性的还是非炎症性的,都表现出相似的疗效。然而,克林霉素+过氧化苯甲酰组合治疗效果的开始明显更快。此外,与阿达帕林+过氧化苯甲酰相比,患者对该组合的耐受性要好得多,并且具有更高的安全性,这是一项涉及382名普通痤疮患者的临床试验所证明的。本文讨论了上述联合药物的各个成分的性质,并比较了两种联合药物的治疗效果、耐受性和安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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