{"title":"Gold(I)-MIC Complexes as a Highly Effective Catalyst for the Cyanosilylation of Carbonyl Compounds Under Solvent-Free Condition","authors":"M. Gangwar","doi":"10.2139/ssrn.3761020","DOIUrl":null,"url":null,"abstract":"Herein, we report the gold(I)-MIC complexes (<b>1-3</b>), bearing mesoionic carbene (MIC) ligands were synthesized. The catalytic activities of these gold(I)-MIC complexes were found to be highly effective catalysts for cyanosilylation of various aldehydes under solvent-free conditions using TMSCN (trimethylsilyl cyanide). The cyano group transfer from TMSCN to aldehydes proceeds at room temperature in the presence of only 5 mol % of Au(I)-MIC catalysts (<b>1-3</b>), to produce value-added cyanohydrin trimethylsilyl ethers in very good to excellent yields within 6 h, from various aldehydes through cyanosilylation process by using trimethylsilyl cyanide reagent at room temperature under solvent-free condition. These reaction conditions are extremely mild and simple and tolerate various functional groups.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"15 1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry eJournal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2139/ssrn.3761020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Herein, we report the gold(I)-MIC complexes (1-3), bearing mesoionic carbene (MIC) ligands were synthesized. The catalytic activities of these gold(I)-MIC complexes were found to be highly effective catalysts for cyanosilylation of various aldehydes under solvent-free conditions using TMSCN (trimethylsilyl cyanide). The cyano group transfer from TMSCN to aldehydes proceeds at room temperature in the presence of only 5 mol % of Au(I)-MIC catalysts (1-3), to produce value-added cyanohydrin trimethylsilyl ethers in very good to excellent yields within 6 h, from various aldehydes through cyanosilylation process by using trimethylsilyl cyanide reagent at room temperature under solvent-free condition. These reaction conditions are extremely mild and simple and tolerate various functional groups.