Determinants of Adherence to Option B+ Antiretroviral Therapy among HIV Positive Pregnant Women Attending Antenatal Clinics at Tertiary Health Institutions in Anambra State

Esther A Silas, C. Nwankwo
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Abstract

Purpose: The study ascertained determinants of adherence to option B+ antiretroviral therapy (ART) among HIV positive pregnant women attending antenatal clinics at tertiary health institutions in Anambra state. Methodology: A cross-sectional descriptive design was adopted in conducting the study among HIV positive pregnant women attending antenatal clinics at tertiary health institutions in Anambra state. A sample size of one hundred and forty six (146) HIV positive pregnant women was selected by purposive and convenience sampling techniques. Adult AIDS Clinical Trial Group (AACTG) standardized questionnaire was used in data collection which were analyzed with IBM SPSS software database (version 25). Chi square was used for test of hypotheses at p < 0.05 level of significance. Findings: Results revealed that the women with parity less than 4 (105(89%) were more adherent to ART; the women with primary education as highest level of education (13(92.9%) were more adherent to ART; the women within the age range 15-25 years (32(97%) were adherent; the women working in the informal sector (31 (96.9%) were more adherent to ART. The study also showed that there is no significant relationship between the women’s level of education, parity, age and adherence to ART but there is significant relationship between the women’s occupation and adherence to ART. From the study, it was ascertained that the HIV positive pregnant woman’s parity, level of education and age are not determinants of adherence to Option B+ ART but occupation of the women is. Recommendations: Health care providers or mentor mothers in the health care facilities should give more attention to the HIV positive pregnant women working in the informal sector and unemployed than the women working in the formal sector in regards to their adherence to ART.  
阿南布拉州三级卫生机构产前门诊的艾滋病毒阳性孕妇坚持B+抗逆转录病毒治疗的决定因素
目的:该研究确定了在阿南布拉州三级卫生机构产前诊所就诊的艾滋病毒阳性孕妇坚持B+抗逆转录病毒治疗(ART)的决定因素。方法:在阿南布拉州三级卫生机构产前诊所就诊的艾滋病毒阳性孕妇中,采用横断面描述性设计进行研究。采用目的抽样和方便抽样的方法,选取146例HIV阳性孕妇为样本。采用成人艾滋病临床试验组(Adult AIDS Clinical Trial Group, AACTG)标准化问卷收集数据,采用IBM SPSS软件数据库(version 25)进行分析。假设检验采用卡方检验,p < 0.05显著性水平。结果显示胎次小于4胎次的妇女(105例(89%))更坚持抗逆转录病毒治疗;初等教育程度最高的妇女(13人,占92.9%)更坚持抗逆转录病毒治疗;15 ~ 25岁女性中32例(97%)为粘连;在非正规部门工作的妇女(31人(96.9%))更坚持抗逆转录病毒治疗。研究还表明,妇女的受教育程度、性别、年龄与抗逆转录病毒治疗依从性之间没有显着关系,但妇女的职业与抗逆转录病毒治疗依从性之间存在显着关系。从研究中可以确定,艾滋病毒阳性孕妇的胎次、教育水平和年龄不是坚持B+ ART方案的决定因素,而是妇女的职业。建议:在坚持抗逆转录病毒治疗方面,卫生保健提供者或卫生保健机构的指导母亲应比在正规部门工作的妇女更关注在非正规部门工作和失业的艾滋病毒阳性孕妇。
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