Prognostic Value of Serum Cholesterol and Triglyceride in Septic and Non-septic Patients: Randomized Double-blinded Study

D. Rashwan, S. Rashwan, W. Hassan, Doaa Moaz Sayem
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引用次数: 1

Abstract

Aims: Is to evaluate the difference between the level of serum cholesterol and triglyceride in septic and non-septic patients and to find a correlation between the level of cholesterol and triglyceride and Acute Physiology and Chronic Health Evaluation Score and quick Sequential Organ Failure Assessment score. Materials and Methods: 95 patients admitted to the SICU, septic patients (group S, n=50) or non-septic patients (NS, n=45). Main outcome measures: length of ICU stay, 28-day mortality, days on mechanical ventilation, (APACHE II) scores, (qSOFA) scores, serum cholesterol, and triglyceride on days 0 and on 1st, 3rd, 7th,10th and 14th day. Result: Cholesterol level (mg/dL) Day 0: It was statistically significant lower in septic group (S) compared to the non-septic group (NS); it was 119.4 ± 29.33 versus 131.2 ± 35.37 (p value=0.037). Day 1: It was statistically significantly lower in the septic group (S): 103.6 ± 29.19 than the non-septic group (NS):123.56 ± 36.50 (p value E‚0.001). Day 3: It was statistically significantly lower in the septic group (S) 80.7 ± 26.87 than in the non-septic group (NS) 124.84 ± 32.4 (p value <0.001). Triglyceride level (mg/dL): Day 1: Was statistically significantly higher in the septic group (S): 151.5 ± 54.79, than the non-septic group (NS): 112.14 ± 33.02, (p value <0.001). Day 3: It was statistically significant higher in the septic group (S):185.1 ± 43.1 than the non-septic group (NS): 113.5 ± 39.56), (p value <0.001). Conclusion: Cholesterol levels decreased markedly and triglyceride levels increased in patients with sepsis compared to non-septic patients, in the septic patients there was increasing in length of ICU stay, higher qSOFA, and APACHE II scores.
血清胆固醇和甘油三酯在脓毒症和非脓毒症患者中的预后价值:随机双盲研究
目的:评价脓毒症患者与非脓毒症患者血清胆固醇和甘油三酯水平的差异,探讨胆固醇和甘油三酯水平与急性生理与慢性健康评估评分和快速序期器官衰竭评估评分的相关性。材料与方法:SICU收治的患者95例,脓毒症患者(S组,n=50)和非脓毒症患者(NS组,n=45)。主要观察指标:ICU住院时间、28天死亡率、机械通气天数、(APACHE II)评分、(qSOFA)评分、第0天和第1、3、7、10、14天的血清胆固醇和甘油三酯。结果:胆固醇水平(mg/dL)第0天:脓毒症组(S)低于非脓毒症组(NS);分别为119.4±29.33∶131.2±35.37 (p值=0.037)。第1天:脓毒症组(S): 103.6±29.19低于非脓毒症组(NS):123.56±36.50,差异有统计学意义(p < 0.001)。第3天:脓毒症组(S) 80.7±26.87低于非脓毒症组(NS) 124.84±32.4 (p值<0.001)。甘油三酯水平(mg/dL):第1天:脓毒症组(S): 151.5±54.79,高于非脓毒症组(NS): 112.14±33.02,差异有统计学意义(p值<0.001)。第3天:脓毒症组(S):185.1±43.1高于非脓毒症组(NS): 113.5±39.56,差异有统计学意义(p值<0.001)。结论:与非脓毒症患者相比,脓毒症患者的胆固醇水平明显下降,甘油三酯水平升高,脓毒症患者的ICU住院时间增加,qSOFA和APACHE II评分较高。
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