Fluconazole Prophylaxis in Neonates (Non-Systematic) Literature Review

A. Almulhim
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Abstract

Background: Nosocomial infection remains an important contributing factor for morbidity and mortality in neonates. Coagulase-negative staphylococci have emerged as the predominant pathogens of late onset sepsis. This is followed by staphylococcus aurous, gram negative bacilli, and fungi. Old studies noted that mortality due to candidemia was higher in infants weigh less than 2000 g after being exposed to risk factors. The prophylactic use of fluconazole for the prevention of IC in extremely low birth weight was first reported in 2001. Methods: Current guidelines from Europe and North America that refer to the treatment of fungal infections are included. Literature search was performed using Medline, Scopus and Cochrane Central Register of Controlled Trials through March, 2016. Conclusion: Mortality was not different in early studies. However, recent studies concluded that mortality was reduced in the fluconazole arms. Risk-based approach towards fluconazole prophylaxis seems to be safe and effective.
新生儿氟康唑预防(非系统)文献综述
背景:医院感染仍然是新生儿发病率和死亡率的重要因素。凝固酶阴性葡萄球菌已成为晚期脓毒症的主要病原体。其次是金黄色葡萄球菌、革兰氏阴性杆菌和真菌。以前的研究指出,在暴露于危险因素后,体重低于2000克的婴儿因念珠菌引起的死亡率更高。2001年首次报道了在极低出生体重中预防性使用氟康唑预防IC。方法:目前来自欧洲和北美的治疗真菌感染的指南包括在内。文献检索使用Medline、Scopus和Cochrane Central Register of Controlled Trials,截止到2016年3月。结论:早期研究中死亡率无差异。然而,最近的研究得出结论,氟康唑组的死亡率降低了。基于风险的氟康唑预防方法似乎是安全有效的。
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