Growth hormone neurosecretory dysfunction.

B. Bercu,, F. Diamond
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引用次数: 64

Abstract

The basis for understanding clinical disorders in the neuroregulation of GH secretion is derived from the complexity of the CNS-hypothalamic-pituitary axis. Studies in animals and humans demonstrate an anatomic, physiological and pharmacological evidence for neurosecretory control over GH secretion including neurohormones (GRH, somatostatin), neurotransmitters (dopaminergic, adrenergic, cholinergic, serotonergic, histaminergic, GABAergic), and neuropeptides (gut hormones, opioids, CRH, TRH, etc). The observation of a defect in the neuroregulatory control of GH secretion in CNS-irradiated humans and animals led to the hypothesis of a disorder in neurosecretion, GHND, as a cause for short stature. We speculate that in this heterogeneous group of children a disruption in the neurotransmitter-neurohormonal functional pathway could modify secretion ultimately expressed as poor growth velocity and short stature.
生长激素神经分泌功能障碍。
理解生长激素分泌的神经调节的临床障碍的基础是来自中枢神经系统-下丘脑-垂体轴的复杂性。动物和人类的研究证明了神经分泌控制生长激素分泌的解剖学、生理学和药理学证据,包括神经激素(GRH、生长抑素)、神经递质(多巴胺能、肾上腺素能、胆碱能、血清素能、组胺能、gaba能)和神经肽(肠道激素、阿片类药物、CRH、TRH等)。在中枢神经系统辐射的人类和动物中观察到生长激素分泌的神经调节控制缺陷,导致神经分泌紊乱的假设,GHND,是身材矮小的原因。我们推测,在这一异质儿童群体中,神经递质-神经激素功能通路的破坏可能会改变分泌,最终表现为生长速度差和身材矮小。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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