The Influence of Partial Androgen Deficiency in Aging Men (PADAM) on the Development of Benign Prostatic Hyperplasia and Prostate Cancer

Abstract

Once people reach 40 years of age, they have a decrease in their pool of pluripotent stem cells, and show a violation of tissue renewal, a decrease in the number of cell-producers of testosterone (Leidig cells) and a reduction in testosterone circulating in the blood. Partial androgen deficiency in aging men violates division and differentiation of androgen-dependent cells and increases the risk for development of benign prostatic hyperplasia and prostate cancer. The recovery of testosterone production and regeneration helps make a decrease in proliferative activity, and the rehabilitation of regulation of androgen-dependent cells of the prostate and other tissues and organs, as well as reduce insulin resistance among older men.