A. Terakawa, K. Ishii, S. Matsuyama, Y. Kikuchi, T. Kawamura, Y. Takahashi, Y. Miura, M. Karahashi, K. Kusano, H. Yamazaki, Y. Funaki, K. Mizuno, N. Ito, S. Wada, K. Sera
{"title":"Concentration of cisplatin-incorporated polymeric micelles in a murine solid tumor evaluated using PIXE analysis","authors":"A. Terakawa, K. Ishii, S. Matsuyama, Y. Kikuchi, T. Kawamura, Y. Takahashi, Y. Miura, M. Karahashi, K. Kusano, H. Yamazaki, Y. Funaki, K. Mizuno, N. Ito, S. Wada, K. Sera","doi":"10.1142/S0129083514500053","DOIUrl":null,"url":null,"abstract":"We report an elemental analysis of murine solid tumors treated with cisplatin-incorporated polymeric micelles (NC-6004) to evaluate the concentration of the drug in the tumor tissue using conventional particle-induced X-ray emission (PIXE) analysis, as well as the spatial distribution in the tumor section using sub-millimeter PIXE analysis. The results reveal that the platinum concentration in the tumor treated with NC-6004 was higher than in that treated with cisplatin, whereas no significant difference was found in platinum concentration between NC-6004 and cisplatin samples in the normal tissue. This suggests that NC-6004 can both provide therapeutic efficacy and reduce the side effects caused by conventional treatment using cisplatin. These results show that PIXE analysis is a powerful tool for research into drug delivery systems.","PeriodicalId":14345,"journal":{"name":"International Journal of PIXE","volume":"12 1","pages":"41-47"},"PeriodicalIF":0.0000,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of PIXE","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1142/S0129083514500053","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
We report an elemental analysis of murine solid tumors treated with cisplatin-incorporated polymeric micelles (NC-6004) to evaluate the concentration of the drug in the tumor tissue using conventional particle-induced X-ray emission (PIXE) analysis, as well as the spatial distribution in the tumor section using sub-millimeter PIXE analysis. The results reveal that the platinum concentration in the tumor treated with NC-6004 was higher than in that treated with cisplatin, whereas no significant difference was found in platinum concentration between NC-6004 and cisplatin samples in the normal tissue. This suggests that NC-6004 can both provide therapeutic efficacy and reduce the side effects caused by conventional treatment using cisplatin. These results show that PIXE analysis is a powerful tool for research into drug delivery systems.
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