The central nervous system as an initiator of multiple organ dysfunction syndrome: a mini-review

Abstract

In recent years, it has become clear that prognosis after various types of acute brain injury (cranial trauma, stroke, subarachnoid hemorrhage) is related not only to admission or post-reuscitation Glasgow coma score, but to the degree of distant, concomitant organ failures. Suggested mechanisms accounting for these processes are massive catecholamine secretion at the moment of the initial injury, secretion of proinflammatory cytokines, alterations in coagulation state, infections and complications of CPP-directed therapy .