EFFECT OF Tanacetum parthenium ON SERUM AMYLOID A AND SIALIC ACID IN DOGS WITH PSEUDOMONAS AERUGINOSA SKIN INFECTION

June 1 Pub Date : 2020-03-25 DOI:10.36899/japs.2020.3.0076
M. Andonova
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Abstract

The еffect of Tanacetum parthenium (feverfew) on serum amyloid A (SAA) and free sialic acid (SA) were investigated in dogs. The animals were divided into three groups: healthy dogs (Group I; n=5), dogs infected subcutaneously with 1×108 CFU/mL field P. aeruginosa culture (Group II; n=5) and infected dogs treated with feverfew (90 mg standardised extract, 0.7% parthenolide) (Group III; n=5). Oral phytopreparation (2 capsules daily) intake began from post infection hour 4 and lasted 6 days. SAA concentrations increased insignificantly in infected dogs (16 mg/L) while infected dogs treated with feverfew exhibited more than 100-fold increase between post infection hours 24–72 vs Group II. Substantial differences (p<0.01) were identified vs Groups I and II at post infection hour 4, 48 and 72, but one day after feverfew discontinuation (day 7), they were not found out. Serum SA was low in controls (1.65–2.3 mmol/L) increasing by hour 72 in Groups II and III (p<0.01) to 2.8 and 3.49 mmol/L respectively. Positive correlation between both studied markers was present only in infected dogs receiving feverfew (Spearman’s coefficient of rank correlation=0.410, P=0.0086, n=40). Tanacetum parthenium is reported to have medicinal activity in our canine skin infection model.
parthenium对铜绿假单胞菌皮肤感染犬血清淀粉样蛋白A和唾液酸的影响
研究了小白菊(Tanacetum parthenium,简称小白菊)对犬血清淀粉样蛋白A (SAA)和游离唾液酸(SA)的影响。这些动物被分为三组:健康犬(第一组;n=5),皮下感染1×108 CFU/mL现场铜绿假单胞菌培养(II组;n=5)和用小白菊(90 mg标准提取物,0.7% parthenolide)治疗的感染犬(III组;n = 5)。从感染后第4小时开始口服植物修复剂(每日2粒),持续6 d。感染犬的SAA浓度增加不显著(16 mg/L),而感染犬在感染后24-72小时内与第二组相比,用小白菊治疗的SAA浓度增加了100倍以上。感染后4小时、48小时和72小时与ⅰ组和ⅱ组比较,差异有统计学意义(p<0.01),停药后1天(第7天)差异无统计学意义(p<0.01)。对照组血清SA较低(1.65 ~ 2.3 mmol/L),ⅱ组和ⅲ组在72 h后分别升高至2.8和3.49 mmol/L (p<0.01)。两种标记物之间的正相关仅在接受小黄菊治疗的感染犬中存在(Spearman等级相关系数=0.410,P=0.0086, n=40)。据报道,在我们的犬皮肤感染模型中有药用活性。
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