UJI EFEKTIVITAS EKSTRAK ETANOL HERBA KROKOT (Portulaca oleracea L.) SECARA Topical UNTUK Reepitelisasi PENYEMBUHAN LUKA INSISI PADA TIKUS PUTIH (Rattus norvegicus)

Jurnal Penelitian Farmasi & Herbal Pub Date : 2021-10-31 DOI:10.36656/jpfh.v4i1.750

Rani Ardiani

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Abstract

The krokot is a weed that usually grows in plantations. In scientific language, purslane is called Portulaca oleracea L. Purslane is well-known as a nutritious plant in several countries such as China, Mexico, and Greece. In Indonesia, purslane is also known to have uses, or a substitute for ginseng. This aims of the study to determine the effectiveness of purslane herb ethanol extract ointment on wound healing in white rats. This research was conducted using an experimental method. In this study, phytochemical screening and simplicia characterization were carried out. Incision wound healing effect was tested on 25 male white rats with 5 treatment subgroups, namely positive control, negative control, purslane herb ethanol extract ointment 10%, purslane herb ethanol extract ointment 20%, purslane herb ethanol extract ointment 30%. The ointment base used is Vaseline album, liquid paraffin, and solid paraffin. All formulations of purslane herb 10%, 20% and 30%, met the requirements for evaluation of ointment preparations. Phytochemical screening results showed positive containing flavonoids, tannins and saponins. The results of the characterization of purslane herb simplicia powder obtained water content of 8.37%, water soluble extract content of 11.35%, ethanol soluble extract content of 10.99%, total ash content of 7.46% and acid insoluble ash content of 0.88%. The average results of observation of incision wounds in white rats were concentrations of 10% (22 mm) for 14 days, 20% (0.1 mm) for 14 days, 30% (0.04 mm) for 14 days. While the positive control (betadine ointment) was (0 mm) and the negative control (ointment base) was (0.42 mm). It can be concluded that purslane herb ethanol extract can provide effectiveness and antioxidants for wound healing in white rats. The purslane herb 30% ethanol extract has almost comparable effectiveness with betadine ointment in healing incisional wounds in white rats.

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测试KROKOT草药乙醇提取物(葡聚糖oleracea L)的效力。适用于白老鼠腹部伤口的愈合锐化(Rattus norvegicus)

龙葵是一种杂草，通常生长在种植园里。在科学语言中，马齿苋被称为马齿苋L.马齿苋在中国、墨西哥和希腊等几个国家被认为是一种营养丰富的植物。在印度尼西亚，马齿苋也被认为是人参的替代品。研究马齿苋乙醇提取物软膏对大鼠创面愈合的影响。这项研究是用实验方法进行的。在本研究中，进行了植物化学筛选和单株鉴定。以25只雄性大鼠为实验对象，分为5个治疗亚组，即阳性对照组、阴性对照组、马齿苋乙醇提取物软膏10%、马齿苋乙醇提取物软膏20%、马齿苋乙醇提取物软膏30%。使用的软膏基料为凡士林、液体石蜡和固体石蜡。马齿苋10%、20%、30%的配方均满足软膏制剂的评价要求。植物化学筛选结果显示，黄酮类、单宁类、皂苷类阳性。表征结果表明，马齿苋粉含水量为8.37%，水溶性浸出物含量为11.35%，乙醇可溶性浸出物含量为10.99%，总灰分含量为7.46%，酸不溶灰分含量为0.88%。大鼠切口创面观察平均浓度为10% (22 mm)、20% (0.1 mm)、30% (0.04 mm)，持续14天。阳性对照(betadine软膏)为(0 mm)，阴性对照(膏底)为(0.42 mm)。由此可见，马齿苋乙醇提取物具有促进大鼠创面愈合的作用和抗氧化作用。马齿苋草药30%乙醇提取物在愈合大鼠切口伤口方面几乎具有与倍他定软膏相当的效果。

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Jurnal Penelitian Farmasi & Herbal

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