Metabolic accompaniment of individual immune responses to chronic stress in female rats

Abstract

. We have previously shown that the immune responses of female rats to chronic immobilization-aversion stress are ambiguous and can be grouped into at least three clusters. The aim of this study is to identify the peculiarities of metabolism in different variants of the immune response to chronic stress in the same animals. Material and methods . The experiment was performed on 60 healthy Wistar female rats weighing 220-300 g. 10 animals remained intact, and the other rats 6 days subjected to moderate stress by daily 30-minute immobilization. The day after the completion of the stressing course we determined the plasma levels of the electrolytes (calcium, magnesium, phosphates, potassium); nitrogenous metabolites (creatinine, urea, uric acid, bilirubin); middle mass molecules, amylase, glucose, cholesterol as well as lipids peroxidation parameters (diene conjugates, malonic dialdehyde, catalase plasma and superoxide dismutase erythrocytes).The level of sodium determined in erythrocytes. Most of the listed parameters of