Isolation and Chemical Characterization of Essential oil of Saussurea simpsoniana

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2011-11-25 DOI:10.5530/RJPS.2011.3.11

M. S. Sandhyavali, P. S. Sundari, Prabhakar Bhavikatti

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引用次数: 1

Abstract

A B S T R A C T Inflorescence of Saussurea simpsoniana (Asteraceae) grown in Himalayas were used traditionally in treatment of fever, snake bite etc.The present work was undertaken to extract essential oil from Saussurea simpsoniana and identifying its chemical composition.Essential oil was extracted by hydrodistillation. Chemical constituents of the essential oil were separated and identified by means of gas chromarography / Mass spectroscopy (GC-MS). The chromatographic analysis of oil showed the presence of totally 18 constituents. The main components were 5, 8, 11, 14, 17- eicosapentaenoic acid methyl ester (65.42%), 9, 12, 15- octadecatrien-1-ol (14.64%), caryophyllene oxide (2.19%), cedren-13-ol (2.12%) and verrucarol (1.96%). The remaining 13 compounds were found to be in minute quantities. The physicochemical properties of the oil were determined as Specific gravity 1.023g/cc, Specific rotation 21.02, Optical rotation 0.0214 and Refractive index 1.5216. The study indicates that sesquiterpenoids are major components accounting for 88% in the isolated oil. Physicochemical standards were determined for the isolated oil.

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雪莲挥发油的分离及化学性质研究

A B, S, T, R, A, C, T, A, C, T，山雪莲(Asteraceae)的花序，传统上用于治疗发烧，蛇咬伤等。本研究从山雪莲中提取精油并鉴定其化学成分。用加氢蒸馏法提取精油。采用气相色谱-质谱(GC-MS)技术对挥发油的化学成分进行分离鉴定。经色谱分析，油中共含有18种化学成分。主要成分为5、8、11、14、17-二十碳五烯酸甲酯(65.42%)、9、12、15-十八碳烯-1-醇(14.64%)、石竹烯氧化物(2.19%)、雪松-13-醇(2.12%)和疣芦醇(1.96%)。其余13种化合物的含量极低。测定该油的理化性质为:比重1.023g/cc，比旋光度21.02，旋光度0.0214，折射率1.5216。研究表明，倍半萜是分离油的主要成分，占88%。确定了分离油的理化标准。

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RGUHS Journal of Pharmaceutical Sciences

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