Synthesis of 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives as new anticancer agents

Q2 Chemistry

Current Chemistry Letters Pub Date : 2022-01-01 DOI:10.5267/j.ccl.2021.8.004

Anees Pangal, Yusufi Mujahid, Bajarang Desai, J. Shaikh, K. Ahmed

引用次数: 1

Abstract

Under solvent free conditions and in presence of a base 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives were synthesized by grinding technique. Structural investigations were carried out with IR studies, HRMS, 1HNMR and 13CNMR. The compounds were checked for their in vitro anticancer activities against three different human cancer cell lines viz human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa) and human oral squamous cell carcinoma (SCC-40) using SRB method. All the title compounds showed low toxicity towards non-malignant PBMC cells indicating their tumour selectivity. The compounds exhibited good in vitro anti-proliferative potency at lower concentrations against HeLa and MCF-7 cell lines and remain moderately active against SCC-40.

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3-(2-(取代-(三氟甲基)苯胺)乙酰基)- 2h -2- 1衍生物的合成

在无溶剂条件下，在碱的存在下，用研磨法合成了3-(2-(取代-(三氟甲基)苯胺)乙酰基)- 2h -2- 1 -铬衍生物。结构研究采用IR研究、HRMS、1HNMR和13CNMR进行。采用SRB法对3种不同的人乳腺癌细胞系(MCF-7)、人宫颈癌细胞系(HeLa)和人口腔鳞状细胞癌(SCC-40)进行体外抑癌活性检测。所有标题化合物对非恶性PBMC细胞均显示低毒性，表明其具有肿瘤选择性。这些化合物在较低浓度下对HeLa和MCF-7细胞系具有良好的体外抗增殖能力，对SCC-40保持中等活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Chemistry Letters Chemistry-Chemistry (all)

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

20 weeks

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