Impaired memory by hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic fields is ameliorated by thymoquinone

Toxicological & Environmental Chemistry Pub Date : 2022-01-02 DOI:10.1080/02772248.2022.2051509

S. Ustunova, Aysun Kılıç, H. Bulut, E. Gurel-Gurevin, A. H. Eriş, I. Meral

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引用次数: 2

Abstract

Abstract The protective effects of thymoquinone on learning and memory abilities and on hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic field radiation at s strength of 6.0 ± 0.5 V/m for 1 h on each of 15 days was studied. Thymoquinone-treatment (10 mg/kg/day) of radiation-exposed rats resulted in better performance than that of radiation-exposed rats not receiving thymoquinone. Electromagnetic field-exposure led to increased hippocampal superoxide dismutase, glutathione peroxidase, and malondialdehyde levels and to lowered brain-derived neurotrophic factor level; thymoquinone treatment ameliorated all four parameters. Also, in the electromagnetic field-exposed group, N-methyl-D-aspartate receptor expression decreased, and gamma-aminobutyric-acid alpha receptor expression increased, which was reversed by thymoquinone treatment. In conclusion, treatment with the thymoquinone ameliorated the impact of the exposure to EMF and provided a hint on the mechanism involving oxidative stress.

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百里醌可改善900 MHz电磁场下大鼠海马氧化应激引起的记忆损伤

摘要:研究了百里醌对大鼠学习记忆能力和海马氧化应激的保护作用，实验时间为15 d，每次1 h，频率为6.0±0.5 V/m的900 MHz电磁场辐射。辐射暴露大鼠经百里醌治疗(10 mg/kg/d)后，其运动性能优于未接受百里醌治疗的辐射暴露大鼠。电磁场暴露导致海马超氧化物歧化酶、谷胱甘肽过氧化物酶和丙二醛水平升高，脑源性神经营养因子水平降低;百里醌治疗改善了所有四个参数。电磁场暴露组n -甲基- d-天冬氨酸受体表达减少，γ -氨基丁酸α受体表达增加，百里醌处理逆转了这一趋势。综上所述，百里醌治疗可以改善EMF暴露的影响，并为氧化应激机制提供了线索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Toxicological & Environmental Chemistry

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