Nonalcoholic fatty liver disease and atrial fibrillation: the main markers of this association

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
O. B. Teslenko, S. V. Fedorov, M. Bielinskyi, N. M. Serediuk
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引用次数: 1

Abstract

The prevalence of nonalcoholic fatty liver disease (NAFLD) and atrial fibrillation (AF) has increased globally in recent years. According to recent studies, NAFLD and AF affect approximately 32 % and 0.51 % of the general population, respectively. Aim. To examine the association between NAFLD and AF by using the FibroTest-4 (FIB-4) and the NAFLD Fibrosis score (NFS) and measuring periostin levels. Materials and methods. In this study, we enrolled 96 patients diagnosed with NAFLD and divided them in two groups, the main group – 35 patients with NAFLD + AF and the control group – 61 patients with NAFLD alone. NFS and FIB-4 indices were calculated and serum periostin level was measured. Results. The NAFLD + AF group had higher levels of periostin (10.80 ± 1.60 ng/ml vs. 9.80 ± 1.75 ng/ml, p < 0.001) and higher NFS (-1.05 ± 1.46 vs. -2.65 ± 1.63, p < 0.001) and FIB-4 scores (1.34 ± 0.86 vs 1.07 ± 0.60, p = 0.048). Periostin has been found to be associated with the risk of NAFLD + AF with an OR of 2.079 (95 % CI: 1.418–3.048, p < 0.001). Similar results were with NFS (OR = 3.233, 95 % CI: 1.970–5.303, p < 0.001) and FIB-4 (OR = 2.498, 95 % CI: 1.109–5.627, p = 0.027). The receiver operating characteristic (ROC) analysis was performed using three variables, NFS, FIB-4 and periostin, to determine their ability to distinguish between patients with NAFLD + AF and NAFLD alone. The results have shown that the NFS had the highest area under the curve (AUC) with a value of 0.868 (95 % CI: 0.792–0.943, p < 0.001), indicating excellent discriminatory ability. FIB-4 had an AUC of 0.651 (95 % CI: 0.537–0.765, p = 0.014), while periostin had an AUC of 0.759 (95 % CI: 0.660–0.858, p < 0.001). Conclusions. These findings have suggested a strong association between NAFLD and AF and highlighted the importance of considering AF as a potential complication in patients with NAFLD. Both the use of the FIB-4 and NFS indices and measurement of periostin levels have been proved to be effective in detecting this association.
非酒精性脂肪性肝病和心房颤动:这种关联的主要标志
近年来,非酒精性脂肪性肝病(NAFLD)和心房颤动(AF)的患病率在全球范围内有所增加。根据最近的研究,NAFLD和AF分别影响大约32%和0.51%的普通人群。通过使用FibroTest-4 (FIB-4)和NAFLD纤维化评分(NFS)以及测量骨膜蛋白水平来检查NAFLD与房颤之间的关系。材料和方法。在这项研究中,我们招募了96名确诊为NAFLD的患者,并将他们分为两组,主要组(35名NAFLD + AF患者)和对照组(61名单纯NAFLD患者)。计算NFS、FIB-4指标,测定血清骨膜素水平。NAFLD + AF组患者骨膜蛋白水平较高(10.80±1.60 ng/ml vs. 9.80±1.75 ng/ml, p < 0.001), NFS(-1.05±1.46 vs. -2.65±1.63,p < 0.001), FIB-4评分较高(1.34±0.86 vs. 1.07±0.60,p = 0.048)。研究发现,Periostin与NAFLD + AF的风险相关,OR为2.079 (95% CI: 1.418-3.048, p < 0.001)。NFS (OR = 3.233, 95% CI: 1.970-5.303, p < 0.001)和FIB-4 (OR = 2.498, 95% CI: 1.109-5.627, p = 0.027)的结果相似。使用NFS、FIB-4和periostin三个变量进行受试者工作特征(ROC)分析,以确定它们区分NAFLD + AF和单纯NAFLD患者的能力。结果表明,NFS的曲线下面积(AUC)最高,为0.868 (95% CI: 0.792 ~ 0.943, p < 0.001),具有较好的鉴别能力。FIB-4的AUC为0.651 (95% CI: 0.537 ~ 0.765, p = 0.014),而periostin的AUC为0.759 (95% CI: 0.660 ~ 0.858, p < 0.001)。这些发现提示了NAFLD和房颤之间的强烈关联,并强调了将房颤视为NAFLD患者潜在并发症的重要性。FIB-4和NFS指数的使用以及骨膜蛋白水平的测量已被证明是检测这种关联的有效方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Zaporozhye Medical Journal
Zaporozhye Medical Journal MEDICINE, GENERAL & INTERNAL-
自引率
0.00%
发文量
72
审稿时长
8 weeks
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