Synthesis and Characterization of Rosiglitazone Loaded Magnetic Nanopolymer

Abstract

ABSTRACT The delivery of thiazolidine-2,4-dione therapies directly to the site would ultimately allow higher concentrations of the drug to be delivered and prolong circulation time in vivo to enhance the therapeutic outcome of this drug. Therefore, we sought to design magnetic based polymeric nanoparticles for the site directed delivery of rosiglitazone. We have synthesized Fe3O4 nanoparticles with an average size of 30 ± 2.5 nm and were well characterized by transmission electron microscopy (TEM), quasi elastic light scattering (QELS), and UV-Visible spectroscopic techniques. These Fe3O4 nanoparticles (NPs) were used to prepare rosiglitazone loaded magnetic polymeric nanoparticles (RMN) with an average size of 250 ± 5 nm. Fourier transform infrared (FT-IR) spectroscopy showed the encapsulation of rosiglitazone on the surface of the polymer matrix. The encapsulation of the Fe3O4 NPs on the surface of the polymer was confirmed by elemental analysis. We studied the drug loading efficiency of gelatin polymer...