The Prognostic Value of Preoperative Neutrophil to Lymphocyte Ratio in the Penile Cancer: Meta Analysis

Science Discovery Pub Date : 2021-11-12 DOI:10.11648/J.SD.20210906.12

Yang Zeng, Xie Qun

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Abstract

Objection: To evaluate the preoperative neutrophil to lymphocyte ratio in the prognosis of penile cancer. Methods: From the establishment of the database to January 2021, search for the Cochrane Library, PubMed, EMbase, CNKI, Wanfang database, papers that meet the inclusion and exclusion criteria will be obtained for meta analysis using RevMan 5.1 software and STATA 15.0 software. Results: Include 7 studies with 812 patients. The overall survival rate (HR=2.83 95% CI: 1.96-4.08, P<0.001) and progression-free survival rate (HR=1.62 95% CI: 1.17-2.23, P=0.004) of patients with preoperative high NLR was low; the overall survival of patients with positive lymph node metastasis (HR=4.13 95% CI: 2.47-6.90), P<0.001), progression-free survival (HR=3.88 95% CI: 2.15-5.32, P<0.001) is low; lymph node metastasis rate in patients with low NLR (OR=6.99 95%CI: 3.69-13.24, P<0.001) lower. Conclusions: Preoperative high NLR predicts a shorter overall survival rate and progression-free survival rate in patients with penile cancer. It can be considered that NLR is a simple and effective preoperative inflammatory index for predicting the prognosis of patients with penile cancer. It may provide a new perspective and help for clinical work, which will be good news for patients with penile cancer and clinicians.

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阴茎癌术前中性粒细胞/淋巴细胞比值的预后价值:Meta分析

目的:探讨术前中性粒细胞与淋巴细胞比值对阴茎癌预后的影响。方法:自建库至2021年1月，检索Cochrane Library、PubMed、EMbase、CNKI、万方数据库，使用RevMan 5.1软件和STATA 15.0软件获取符合纳入和排除标准的论文进行meta分析。结果:纳入7项研究，812例患者。术前NLR高的患者总生存率(HR=2.83 95% CI: 1.96 ~ 4.08, P<0.001)和无进展生存率(HR=1.62 95% CI: 1.17 ~ 2.23, P=0.004)较低;淋巴结转移阳性患者的总生存率(HR=4.13 95% CI: 2.47 ~ 6.90)， P<0.001)、无进展生存率(HR=3.88 95% CI: 2.15 ~ 5.32, P<0.001)较低;低NLR患者的淋巴结转移率较低(OR=6.99 95%CI: 3.69 ~ 13.24, P<0.001)。结论:术前高NLR预示着阴茎癌患者较短的总生存率和无进展生存率。可以认为NLR是预测阴茎癌患者预后的简单有效的术前炎症指标。这可能为临床工作提供新的视角和帮助，对阴茎癌患者和临床医生来说都是一个好消息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Science Discovery

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