Principles and Practice of Neuropsychopharmacology

IF 0.2 Q4 PEDIATRICS
C. Stafstrom
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引用次数: 0

Abstract

This compact volume is subtitled, “A Clinical Reference for Residents, Physicians, and Biomedical Scientists.” The book not only emphasizes treatment options for psychopharmacological disorders, but also includes succinct and informative coverage of neurotransmitters, pharmacokinetic principles, and the basics of pharmacodynamics. There are also individual chapters focusing on the treatment of neurological disorders such as headache, stroke, and attentiondeficit hyperactivity disorder. Of most interest to readers of this journal, the authors provide a chapter on antiseizure medications (ASMs). Aside from their use of long-expired nomenclature and seizure/epilepsy classification, the chapter on ASMs is presented at a very basic (i.e., simple) level, approximating the complexity of a beginning medical student. To the authors’ credit, in this 27-page chapter, they attempt to cover ASM mechanisms, types of seizures, and clinical summaries of five “older” ASMs and eight “newer” ASMs. Omitted for both brevity and simplicity are all of the ASMs that have been approved in the past 5 to 10 years. There is brief mention of ASMusage in pregnancy, status epilepticus, and different age populations. For any depth or detail, other references will need to be consulted. Overall, the chapter is poorly written and contains many statements that are not only erroneous but also dangerous. Among these are the assertion that phenobarbital is “commonly used in children as an antiepileptic,” that phenobarbital is “the drug of choice for epilepsy in pregnancy,” and that “once started, antiepileptic agents need to be given for a period of at least 3 years.” From the mechanism perspective, the well-established sodium channel blocker oxcarbazepine is listed as affecting potassium channels (in reality this effect is minimal if at all). There are other misconceptions as well, intermixed with numerous misspellings and grammatical errors. The figures are redundant and the text often proceeds in an illogical manner. It is unlikely that an epileptologist willfind this chapter on ASMs of much novelty or practical use, yet medical students and perhaps residents find some insights, assuming they can separate the truth from errors! On the other hand, epileptologists could well benefit from the authors’ review of other disease-related drug categories entailing medications we do not usually prescribe as they are typically prescribed by other specialists (e.g., antidepressants, antipsychotics, etc.).
神经精神药理学原理与实践
这个紧凑的卷的副标题,“为居民,医生和生物医学科学家的临床参考。”这本书不仅强调精神药理学障碍的治疗选择,而且还包括神经递质,药代动力学原理和药效学基础的简明和信息覆盖。也有个别章节侧重于治疗神经系统疾病,如头痛,中风,和注意力缺陷多动障碍。这本杂志的读者最感兴趣的是,作者提供了一章关于抗癫痫药物(asm)。除了使用早已过时的术语和癫痫/癫痫分类外,关于asm的章节是在一个非常基本(即简单)的水平上呈现的,近似于初学医学生的复杂性。值得作者称赞的是,在这27页的章节中,他们试图涵盖ASM的机制、癫痫类型,以及5个“旧”ASM和8个“新”ASM的临床总结。为了简洁性和简单性,省略了过去5到10年批准的所有asm。简要地提到ASMusage在妊娠、癫痫持续状态和不同年龄人群中的作用。对于任何深度或细节,将需要咨询其他参考资料。总的来说,这一章写得很糟糕,包含了许多不仅错误而且危险的陈述。其中包括:苯巴比妥是“儿童常用的抗癫痫药物”,苯巴比妥是“妊娠期癫痫的首选药物”,“一旦开始服用,抗癫痫药物需要至少服用3年”。从机制的角度来看,公认的钠通道阻滞剂奥卡西平被列为影响钾通道的药物(实际上这种影响很小,如果有的话)。还有其他误解,夹杂着许多拼写错误和语法错误。这些数字都是多余的,而且文章常常以一种不合逻辑的方式进行。癫痫病医生不太可能发现这一章关于asm的内容有什么新奇或实际用途,但医科学生和住院医生可能会发现一些见解,假设他们能区分真相和错误!另一方面,癫痫病医生可以从作者对其他疾病相关药物类别的回顾中获益,这些药物涉及我们通常不开的药物,因为它们通常是由其他专家开的(例如,抗抑郁药,抗精神病药等)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
自引率
0.00%
发文量
21
期刊介绍: The Journal of Pediatric Epilepsy is an English multidisciplinary peer-reviewed international journal publishing articles on all topics related to epilepsy and seizure disorders, epilepsy surgery, neurology, neurosurgery, and neuropsychology in childhood. These topics include the basic sciences related to the condition itself, the differential diagnosis, natural history, and epidemiology of seizures, and the investigation and practical management of epilepsy (including drug treatment, neurosurgery and non-medical and behavioral treatments). Use of model organisms and in vitro techniques relevant to epilepsy are also acceptable. Journal of Pediatric Epilepsy provides an in-depth update on new subjects and current comprehensive coverage of the latest techniques used in the diagnosis and treatment of childhood epilepsy.
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