Assessment of Prolactin Level Among Chronic Renal Failure Patients in Khartoum State

Abstract

Prolactin (PRL) is a protein produced in the lactotroph cells of the anterior pituitary gland. It’s like growth hormone increases in sleep, stress, pregnancy and Chest wall stimulation or trauma. Prolactin production can be stimulated by the hypothalamic peptides, thyrotropin-releasing hormone (TRH), and vasoactive intestinal peptide (VIP). Chronic Kidney Disease (CKD) is a major prevalent disease worldwide associated with low grade systemic inflammation that influences individuals to higher incidence of atherosclerotic complications. Both prolactin clearance and production are altered in CKD. The aim of the current work was to assess the serum prolactin level in Renal Failure or chronic kidney disease in order to acquainting endocrinologists with information of hyperprolactinemia in renal failure. This is a descriptive and practical study, conducted at different dialysis’s centers in Khartoum state during May to October 2014. 106 patents (different ages) with symptoms of renal frailer had been selected for the study. 106 samples collected from patient in dialysis center to confirm that renal failure patient associated with hyperprolactinemia by collection 89 patient samples(60were males and 29 were females) and 17 controls, from different person with varies ages from 18 up to 50 years. In this study, samples of patients that the cause of their renal failure is hypertension were rejected. From the collected data, a descriptive and statistical analysis wascarried out, the histograms which include means, standard deviation and correlation coefficient. All the results give an idea that hyperprolactinemia exist renal failure patients. The results concluded that the prevalence of renal failure is higher in male by 2 fold, chronic renal failure significantly not change in prolactin level, whereas chronic renal failure female patients have higher prolactin level than male. The results of prolactin showed that there was insignificant different in main prolactin level of patient compared with control group that hyperprolactinemia exist in renal failure patients.