The impact of cervical (GTVCRX) and parametrial (GTVLP, GTVRP) volumetric status on efficacy of radiotherapy for uterine cervix cancer in stage IIB and IIIB

Q4 Medicine

Nowotwory Pub Date : 2020-09-03 DOI:10.5603/njo.a2020.0036

E. Telka, B. Maciejewski, L. Hawrylewicz, B. Jochymek, M. Markowska

引用次数: 0

Abstract

Introduction. The impact of volumetric staging of cervix and parametria on treatment outcome after combined BRT and IMRT of 135 cervix cancer patients in stage IIB and IIIB is analysed. Material and methods. Cervical GTVCRX and parametrial (GTVLP, RP) volumes are subdivided into four subgroups. BRT with 30 Gy in three fractions was combined with IMRT 48 Gy in 24 fractions. For GTVCRX ≤35 cm3 5-year local control (LC) was 100%, which decreased to 87% for GTVCRX ≥130 cm3. Results. Cervix and parametrial local recurrence were not higher than 3%. Major failures were periaortal nodes metastases (PNM) occurring during 5-year follow-up. Dose of ≥60 izoGy2.0 effectively prevented the PNM. Underdosage 130 cm3. Conclusion. Although cervix and parametria volumetric status are highly heterogeneous, they turned out to be better prognostic predictors than traditional TNM grading.

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宫颈(GTVCRX)及参数(GTVLP、GTVRP)体积状态对IIB期、IIIB期宫颈癌放疗疗效的影响

介绍。分析135例IIB期和IIIB期宫颈癌患者BRT + IMRT联合治疗后宫颈体积分期及相关参数对治疗结果的影响。材料和方法。宫颈GTVCRX和参数(GTVLP, RP)体积分为四个亚组。3次30 Gy的BRT联合24次48 Gy的IMRT。当GTVCRX≤35 cm3时，5年局部控制率为100%，当GTVCRX≥130 cm3时，5年局部控制率为87%。结果。宫颈及旁系局部复发率不高于3%。主要失败是5年随访期间发生的围壁淋巴结转移(PNM)。≥60剂量izoGy2.0可有效预防PNM。不足130 cm3。结论。虽然子宫颈和参数体积状态是高度异质性的，但它们比传统的TNM分级更能预测预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nowotwory Medicine-Oncology

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： NOWOTWORY Journal of Oncology publishes papers which cover all aspects of oncology but concentrates on clinical studies, both research orientated and treatment orientated, rather than on laboratory studies. Contributions are also welcomed from the fields of epidemiology, tumor pathology, radiobiology and radiation physics.