Short Commentary for “Features of anti-aquaporin 4 Antibody-Seronegative Thai Patients with Neuromyelitis Optica Spectrum Disorders: A Comparison with Seropositive Cases”

Abstract

Copyright: © 2015 Prayoonwiwat N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple sclerosis (MS) in their pathogenesis, clinical manifestations and neuroimaging findings [1]. According to the recent international consensus on diagnostic criteria for neuromyelitis optica spectrum disorders (NMOSD) 2015, the new criteria combine “definite NMO” and “NMOSD” into one term “NMOSD”. NMOSD was stratified further by serologic testing into NMOSD with or without presence of AQP4-antibody together with the 6 core clinical symptoms including clinical syndromes or MRI findings associated with optic nerve, spinal cord, area postrema, other brainstem, diencephalic, or cerebral manifestations. More stringent clinical criteria with MRI findings compatible with those seen in NMOSD are required for a diagnosis of seronegative NMOSD [2].