Effect of liver diseases on hormonal and biochemical parameters in Wistar albino rat

Abstract

The current study was performed to evaluate the effect of acute and chronic hepatotoxicity induced by paracetamol and thioacetamide respectively on serum hormonal levels and biochemical parameters. Female Wistar albino rats were divided into 3 equal groups (C), (P) and (T). Group (C) were kept as control, group (P) were received paracetamol orally (500 mg/kg b.wt) daily for 15 days and those of group (T) were injected thioacetamide (200 mg/kg b.wt) intraperitonialy twice/ week for 90 days. In P group, results revealed significant elevation in liver enzyme activities (ALT, AST and ALP), T4, insulin (7 th day), estrogen (7 th and 15 th days), triglycerides (7 th day) and cholesterol levels throughout the experiment while serum proteins and T4 (15 th day) showed significant decreased values. Whereas, at 90 th days of chronic intoxicated group (T) resulted in significant elevation in liver enzyme activities (ALT, AST and ALP), bilirubin, estrogen, T4, triglycerides (60 th and 90 th days) and T3 (120 th day). While the levels of T4 and cortisol (60 th day), serum total protein, albumin, globulin (90 th day) and insulin (120 th day) showed significant decreased values when compared to control group. In conclusion, both paracetamol and thioacetamide cause different degrees of damage in liver of rats leading to clear changes in their hormonal and biochemical profiles. ARTICLE INFO