Potential Reno-Protective Effects of Telmisartan in Kurd Non-Diabetic Hypertensive Patients in Hawler City

A. I. Muslih
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Abstract

Angiotensin II (AII) type I (AT1) receptor blockers are a well known group of drug that indicated principally for the treatment of hypertension as well as for the protection of kidney function in diabetic patients. Telmisartan is a highly selective angiotensin receptor blocker, and the favourable tolerability profile of telmisartan combined with its long elimination half- life ensure the drug provides pronounced reductions in blood pressure (BP) across the entire 24-hour dosage interval. There is relatively very little data and information available to reveal renoprotective activity of telmisartan in nondiabetic low grade albuminuric Kurd hypertensive patients. Our study explores the effect of telmisartan on mean arterial blood pressure and it also sheds more light on its crucial role in lowering albumin: creatinine ratio in Kurd patients. The results of our study demonstrate that telmisartan reduces mean arterial blood pressure significantly, furthermore the study had explained a significant reduction in albuminuria at the second month of treatment which is regarded as a positive sign of renoprotection.
替米沙坦对霍勒市库尔德非糖尿病高血压患者的潜在保护作用
血管紧张素II (AII) I型(AT1)受体阻滞剂是一组众所周知的药物,主要用于治疗高血压和保护糖尿病患者的肾功能。替米沙坦是一种高度选择性的血管紧张素受体阻滞剂,其良好的耐受性及其较长的消除半衰期确保该药物在整个24小时剂量间隔内提供明显的血压(BP)降低。关于替米沙坦对非糖尿病性低蛋白尿库德族高血压患者的肾保护作用的数据和信息相对较少。我们的研究探讨了替米沙坦对平均动脉血压的影响,也揭示了它在降低库尔德患者白蛋白:肌酐比率方面的关键作用。我们的研究结果表明,替米沙坦显著降低平均动脉血压,此外,研究还解释了在治疗第二个月时蛋白尿的显著降低,这被认为是肾保护的积极迹象。
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